EVALUATION OF LIVE AND INACTIVATED INFLUENZA-A VIRUS-VACCINES IN A MOUSE MODEL
EVALUATION OF LIVE AND INACTIVATED INFLUENZA-A VIRUS-VACCINES IN A MOUSE MODEL
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DOI：
10.1093/infdis/145.3.320
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发表时间：
1982-01-01
影响因子：
6.4
通讯作者：
LIEHL, E
中科院分区：
文献类型：
--
作者：
ARMERDING, D;ROSSITER, H;LIEHL, E
在小鼠中检测了对不同亚型流感病毒的交叉保护免疫的诱导，试图将交叉保护与异型淋巴细胞反应联系起来。活的和灭活的病毒疫苗对同源亚型有保护作用，但对异源亚型只有全病毒保护。活病毒疫苗比灭活病毒疫苗提供了更好的交叉保护。对活的H0N1病毒产生的异型攻击的弱抵抗力可以通过与整个H3N2病毒的交叉刺激和致病性H0N1病毒的重新刺激来增强。异型保护至少持续5个月。活病毒在正常小鼠体内诱导细胞毒性T细胞的交叉反应。需要与异源病毒交叉刺激才能产生二次细胞毒性。全病毒接种后可见明显的交叉反应B淋巴细胞。
Induction of cross-protective immunity against serologically distinct subtypes of influenza A virus in mice was examined in an attempt to correlate cross-protection with heterotypic lymphocyte responses. Live and inactivated virus vaccines protected against the homologous subtype, but only whole virus protected against heterologous subtypes. Live virus vaccines provided better cross-protection than inactivated virus vaccines. A weak defense against heterotypic challenge generated by live H0N1 virus could be boosted by cross-stimulation with whole H3N2 virus and by restimulation with pathogenic H0N1 virus. Heterotypic protection persisted for at least 5 mo. Live viruses induced cross-reactive cytotoxic T cells in normal mice. Cross-stimulation with heterologous virus was required to generate secondary cytotoxicity. Cross-reactive B lymphocytes were evident after inoculation with whole virus.