Oxidized LDL, serum oxidizability and serum lipid levels in patients with breast or ovarian cancer
Oxidized LDL, serum oxidizability and serum lipid levels in patients with breast or ovarian cancer
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DOI：
10.1016/j.clinbiochem.2007.06.007
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发表时间：
2007-10-01
影响因子：
2.8
通讯作者：
Dionyssiou-Asteriou, Amalia
中科院分区：
文献类型：
--
作者：
Delimaris, Loannis;Faviou, Elsa;Dionyssiou-Asteriou, Amalia
目的：通过分析乳腺癌或卵巢癌患者血清的氧化性程度及氧化型低密度脂蛋白(OxLDL)在乳腺癌或卵巢癌中的作用，评价乳腺癌或卵巢癌患者的氧化应激程度。设计与方法：研究对象为32例确诊为乳腺癌或卵巢癌但未接受任何治疗的患者和30名年龄相仿的健康人。氧化应激的评估是通过：(A)血清脂质对氧化的体外敏感性和(B)oxLDL和抗oxLDL自身抗体的检测。结果：乳腺癌和卵巢癌患者的oxLDL水平均高于对照组。此外，乳腺癌患者血清总胆固醇、低密度脂蛋白-胆固醇、抗ox低密度脂蛋白抗体及氧化成分负荷指数--最大二烯生成率(RA)均高于对照组。有统计学意义的证据表明，血清oxLDL水平与乳腺癌和卵巢癌的风险增加有关。结论：oxLDL与恶性肿瘤之间存在相关性，支持氧化应激在癌变过程中的作用，并可能参与了癌变过程。Ox低密度脂蛋白检测的临床评估正在调查中。(C)2007年加拿大临床化学家协会。爱思唯尔公司出版，版权所有。
Objectives: The aim of this study was to evaluate the extent of oxidative stress in patients with breast or ovarian cancer by analyzing the magnitude of serum oxidizability and the involvement of oxidized low-density lipoproteins (oxLDL) in the disease.Design and methods: The study was conducted on 32 patients diagnosed with breast or ovarian cancer but who had not undergone any kind of treatment and 30 healthy individuals of similar age. The evaluation of oxidative stress was assessed by: (a) the ex-vivo susceptibility of serum lipids to oxidation and (b) the detection of oxLDL and anti-oxLDL autoantibodies. Total cholesterol, LDL-cholesterol and HDL-cholesterol were co-estimated.Results: The results indicated that the levels of oxLDL were increased among both breast and ovarian cancer patients as compared to the control subjects. Additionally in patients with breast cancer, serum total cholesterol, LDL-cholesterol, anti-oxLDL antibodies and the maximal rate of diene formation (RA), the index of oxidizable components load, were increased in comparison to controls. There is statistically significant evidence that serum oxLDL levels are associated with increased risk of breast and ovarian cancer.Conclusions: The findings exhibit a correlation between oxLDL and malignancy, supporting the contribution of oxidative stress to carcinogenesis and the possible involvement of oxLDL in the process of malignancy. The clinical evaluation of the oxLDL measurement is under investigation. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.