Genomic Epidemiology Reconstructs the Introduction and Spread of Zika Virus in Central America and Mexico
Genomic Epidemiology Reconstructs the Introduction and Spread of Zika Virus in Central America and Mexico
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DOI：
10.1016/j.chom.2018.04.017
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发表时间：
2018-06-13
影响因子：
30.3
通讯作者：
Pybus, Oliver G.
中科院分区：
文献类型：
--
作者：
Theze, Julien;Li, Tony;Pybus, Oliver G.
寨卡病毒（ZIKV）在美洲的流行确立了ZIKV作为一个主要的公共卫生威胁，并发现其与严重疾病，包括小头畸形的关联。然而，在一些高危地区，特别是中美洲和墨西哥，遗传流行病学仍然有限。我们报告了来自该区域的61个ZIKV基因组，使用ZIKV特异性富集的宏基因组测序生成，并结合联合收割机系统发育，流行病学和环境数据来重建ZIKV传播。这些分析揭示了多个独立的ZIKV引入中美洲和墨西哥。其中一次可能是从巴西经洪都拉斯传入，导致大多数感染，并从2014年底开始在该地区传播ZIKV。多条证据表明该地区ZIKV传播的两年高峰，可能是由蚊子媒介和群体免疫力的不同当地环境条件驱动的。ZIKV在中美洲和墨西哥传播的空间和时间异质性对虫媒病毒监测和疾病控制措施提出了挑战。
The Zika virus (ZIKV) epidemic in the Americas established ZIKV as a major public health threat and uncovered its association with severe diseases, including microcephaly. However, genetic epidemiology in some at-risk regions, particularly Central America and Mexico, remains limited. We report 61 ZIKV genomes from this region, generated using metagenomic sequencing with ZIKV-specific enrichment, and combine phylogenetic, epidemiological, and environmental data to reconstruct ZIKV transmission. These analyses revealed multiple independent ZIKV introductions to Central America and Mexico. One introduction, likely from Brazil via Honduras, led to most infections and the undetected spread of ZIKV through the region from late 2014. Multiple lines of evidence indicate biannual peaks of ZIKV transmission in the region, likely driven by varying local environmental conditions for mosquito vectors and herd immunity. The spatial and temporal heterogeneity of ZIKV transmission in Central America and Mexico challenges arbovirus surveillance and disease control measures.