Magnesium sulfate for the treatment of eclampsia: a brief review.
Magnesium sulfate for the treatment of eclampsia: a brief review.
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DOI：
10.1161/strokeaha.108.527788
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发表时间：
2009-04
期刊：
影响因子：
8.3
通讯作者：
Cipolla MJ
中科院分区：
文献类型：
--
作者：
Euser AG;Cipolla MJ
硫酸镁被广泛用于预防惊厥发作。经验和临床证据支持硫酸镁的有效性;然而，关于其安全性和机制仍存在问题。本文综述了目前支持硫酸镁治疗的可能作用机制和几个争议的证据。提出了几种机制，包括硫酸镁对外周和脑血管舒张的影响，血脑屏障保护，以及作为抗惊厥药。虽然具体的作用机制尚不清楚，但硫酸镁在预防子痫中的作用可能是多因素的。硫酸镁可作为血管扩张剂，在外周血管系统或动脉血管系统中起作用，以降低外周血管阻力和/或缓解血管收缩。此外，硫酸镁还可以保护血脑屏障并限制脑水肿的形成，或者它可以通过中枢抗惊厥作用发挥作用。
Magnesium sulfate is used extensively for prevention of eclamptic seizures. Empirical and clinical evidence supports the effectiveness of magnesium sulfate; however, questions remain as to its safety and mechanism. This review summarizes current evidence supporting the possible mechanisms of action and several controversies for magnesium sulfate treatment. Several mechanisms are presented, including the effects of magnesium sulfate on peripheral and cerebral vasodilation, blood-brain barrier protection, and as an anticonvulsant. Though the specific mechanisms of action remain unclear, the effect of magnesium sulfate in the prevention of eclampsia is likely multi-factorial. Magnesium sulfate may act as a vasodilator, with actions in the peripheral vasculature or the cerebrovasculature, to decrease peripheral vascular resistance and/or relieve vasoconstriction. Additionally, magnesium sulfate may also protect the blood-brain barrier and limit cerebral edema formation, or it may act through a central anticonvulsant action.