Magnetic resonance parkinsonism indices and interpeduncular angle in idiopathic normal pressure hydrocephalus and progressive supranuclear palsy.
Magnetic resonance parkinsonism indices and interpeduncular angle in idiopathic normal pressure hydrocephalus and progressive supranuclear palsy.
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DOI：
10.1007/s00234-020-02500-1
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发表时间：
2020-12
期刊：
影响因子：
2.8
通讯作者：
Brunetti A
中科院分区：
文献类型：
--
作者：
Ugga L;Cuocolo R;Cocozza S;Pontillo G;Elefante A;Quarantelli M;Vicidomini C;De Pandis MF;De Michele G;D'Amico A;de Divitiis O;Brunetti A
特发性正常压力脑积水（iNPH）的临床表现可能与进行性核上性麻痹（PSP）重叠。研究了磁共振帕金森综合征指数（MRPI）、MRPI 2.0和脚间角（IPA），以区分PSP与健康对照（HC）和其他帕金森综合征。我们旨在评估iNPH、PSP和HC组中MRPI、MRPI 2.0和IPA的等效性和差异。我们回顾性招募了来自两家机构的99名受试者（30名iNPH，32名PSP，37名HC）。在1.5 T或3 T扫描仪上获取的MRI检查包括3D T1加权图像，用于测量MRPI、MRPI 2.0和IPA。使用类内相关系数（ICC）研究了评估者间和评估者内可靠性，并使用双单侧t检验（TOST）程序评估iNPH、PSP和HC中的这些标志物。对于所有三项指标，评分者内和评分者间ICC均表现出色（范围= 0.91-0.93）。在iNPH和PSP与HC的比较中，在TOST时发现MRPI和MRPI 2.0存在差异（所有病例均为p < 0.01），且无等效性（所有病例均为p = 1.00）。iNPH和PSP MRPI显示无差异（p = 0.06），也无等效性（p = 0.08）。在相同的两个人群中，MRPI 2.0不等同（p = 0.06）且无差异（p = 0.09）。PSP和HC IPA证明等同（p < 0.01），而iNPH IPA与PSP和HC不同（p < 0.01）且不等同（p = 0.96和0.82）。MRPI和MRPI 2.0在iNPH和PSP中显著重叠，存在误诊风险，因此可能无助于鉴别诊断。本文的在线版本（10.1007/s 00234 -020-02500-1）包含补充材料，可供授权用户使用。
The clinical presentation of idiopathic normal pressure hydrocephalus (iNPH) may overlap with progressive supranuclear palsy (PSP). The Magnetic Resonance Parkinsonism Index (MRPI), MRPI 2.0, and the interpeduncular angle (IPA) have been investigated to differentiate PSP from healthy controls (HC) and other parkinsonisms. We aimed to assess equivalences and differences in MRPI, MRPI 2.0, and IPA in iNPH, PSP, and HC groups. We retrospectively recruited 99 subjects (30 iNPH, 32 PSP, 37 HC) from two institutions. MRI exams, acquired on either 1.5 T or 3 T scanners, included 3D T1-weighted images to measure MRPI, MRPI 2.0, and IPA. Inter- and intra-rater reliability was investigated with the intra-class correlation coefficient (ICC), and the two one-sided t tests (TOST) procedure was used to assess these markers in iNPH, PSP, and HC. For all the three measures, intra-rater and inter-rater ICC were excellent (range = 0.91–0.93). In the comparison of iNPH and PSP with HC, differences for MRPI and MRPI 2.0 (p < 0.01 in all cases) and no equivalence (p = 1.00 in all cases) were found at TOST. iNPH and PSP MRPI showed no difference (p = 0.06) and no equivalence (p = 0.08). MRPI 2.0 was not equivalent (p = 0.06) and not different (p = 0.09) in the same two populations. PSP and HC IPA proved equivalent (p < 0.01) while iNPH IPA was different (p < 0.01) and not equivalent (p = 0.96 and 0.82) from both PSP and HC. MRPI and MRPI 2.0 significantly overlap in iNPH and PSP, with risk of misdiagnosis, and for this reason may not be helpful in the differential diagnosis. The online version of this article (10.1007/s00234-020-02500-1) contains supplementary material, which is available to authorized users.
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