Stability of reach-to-grasp movement patterns in Parkinson's disease.
Stability of reach-to-grasp movement patterns in Parkinson's disease.
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帕金森病中伸手抓握运动模式的稳定性。
DOI：
10.1093/brain/120.11.2093
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Adler,CH
中科院分区：
文献类型：
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作者：
Tresilian,JR;Stelmach,GE;Adler,CH
帕金森病患者的表现在两个达到把握任务进行了比较，与年龄匹配的对照组。这项研究的目的是确定帕金森病患者是否有问题，协调同时执行的任务在同一系统的效应器在自然的情况下，以及是否会加剧这种问题的任务难度的增加。我们研究了受试者如何同时执行的运输和把握组件的达到掌握运动的存在下，两种类型的任务需求的变化：（i）增加的需求，准确的数字垫的位置和（ii）使用两个达到掌握任务，即标准的单手任务和双手任务，增加了控制和协调的要求相对于单手任务。如果帕金森病患者有协调问题，他们应该表现出增加的损害与增加的准确性要求和双手任务;任何这样的差异应该是不存在的或小得多的控制组。帕金森病组在所有条件下都表现出严重的损伤，比对照组慢30%左右，抽搐增加，并且有难以控制运动速度的迹象。然而，没有一致的迹象表明，帕金森氏病组的双手任务差异受损，也没有运动赤字增加，增加准确性的要求。帕金森病组和对照组在两个达到掌握任务中的抓握和运输组件进行了类似的协调，帕金森病组在双手任务中有效地协调了两个肢体，并且与对照组的方式相似。这些结果被解释为意味着更高水平（效应器独立水平）的运动编程被保留在帕金森氏病和运动程序的执行不需要通过增加肌肉/关节水平的自由度的数量而受到损害。
The performance of patients with Parkinson's disease on two reach-to-grasp tasks was compared with that of age-matched control subjects. The aim of the study was to determine whether Parkinson's disease patients have problems coordinating concurrently executed tasks within the same system of effectors in a natural context and whether such problems would be exacerbated by increases in task difficulty. We examined how subjects concurrently executed the transport and grasp components of reach-to-grasp movements in the presence of two types of change in task demands: (i) increases in demands for accurate digit pad placement and (ii) use of two reach-to-grasp tasks, i.e. the standard unimanual task and a bimanual task which increased the control and coordination demands relative to the unimanual task. If Parkinson's disease patients have coordination problems they should demonstrate increased impairment with increasing accuracy demands and in the bimanual task; any such differences should be absent or much smaller in the control group. The Parkinson's disease group showed substantial impairments in all conditions, moving about 30% slower than the control group, with much increased jerking and with signs of difficulty controlling the speed of movement. However, there were no consistent indications that the Parkinson's disease group were differentially impaired on the bimanual task nor that movement deficits increased with increasing accuracy requirements. Grasp and transport components were coordinated similarly by Parkinson's disease and control groups in both reach-to-grasp tasks, and the Parkinson's disease group co-ordinated the two limbs in the bimanual task effectively and in a fashion similar to that of the control group. These results are interpreted to mean that higher levels (effector-independent levels) of motor programming are preserved in Parkinson's disease and that execution of a motor programme need not be compromised by increasing the number of muscle-/joint-level degrees of freedom which are used.