Neuropharmacologic treatment of bronchial asthma with the antidepressant tianeptine: A double-blind, crossover placebo-controlled study
Neuropharmacologic treatment of bronchial asthma with the antidepressant tianeptine: A double-blind, crossover placebo-controlled study
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DOI：
10.1016/s0009-9236(98)90156-4
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发表时间：
1998-08-01
影响因子：
6.7
通讯作者：
Lechin, AE
中科院分区：
文献类型：
--
作者：
Lechin, F;van der Dijs, B;Lechin, AE
研究表明，有症状的哮喘患者血浆中游离5-羟色胺水平升高，此外，有症状的哮喘儿童血浆中游离5-羟色胺浓度与临床状态呈正相关，与肺功能（1秒用力呼气量[FEV 1]）呈负相关。因此，降低血浆中游离5-羟色胺的浓度可能有助于治疗儿童哮喘。我们研究了噻奈普汀治疗这些患者的有效性，噻奈普汀是已知的唯一能够降低血浆中游离5-羟色胺水平并增强血小板摄取的药物。在一项双盲交叉试验中，儿童随机接受噻奈普汀或安慰剂或两者。试验持续52周，噻奈普汀引起临床评分和游离血清素血浆水平的急剧和突然下降以及肺功能的增加。
Studies have shown the levels of free serotonin in plasma are increased in symptomatic patients with asthma, In addition, the concentration of free serotonin in symptomatic children with asthma correlates positively with clinical status and negatively with pulmonary function (forced expiratory volume in 1 second [FEV1]). Thus, reducing the concentration of free serotonin in plasma may be useful in treating children with asthma, We studied the effectiveness of tianeptine in treating these patients, Tianeptine is the only drug known to be able to reduce the level of free serotonin in plasma and to enhance the uptake by platelets, Sixty-nine of the 82 children with asthma initially enrolled participated in this study. Children were randomized to receive tianeptine or placebo or both in a double-blind crossover trial. The trial lasted 52 weeks, Tianeptine provoked a dramatic and sudden decrease of both clinical rating and free serotonin plasma levels and an increase in pulmonary function.