Incidental Non-secreting Adrenal Masses in Cancer Patients: Intra-individual Comparison of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography with Computed Tomography and Shift Magnetic Resonance Imaging
Incidental Non-secreting Adrenal Masses in Cancer Patients: Intra-individual Comparison of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography with Computed Tomography and Shift Magnetic Resonance Imaging
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DOI：
10.1177/147323001003800226
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发表时间：
2010-03-01
影响因子：
1.6
通讯作者：
Hoeffken, H.
中科院分区：
文献类型：
--
作者：
Gratz, S.;Kemke, B.;Hoeffken, H.
综合f -18氟脱氧葡萄糖正电子发射断层扫描和计算机断层扫描（FDG PET/CT）对癌症患者良性和恶性偶发非分泌性肾上腺肿块的鉴别能力进行了评估。结果比较了CT和移位磁共振成像（MRI）的结果。回顾性分析了1832例接受FDG PET/CT扫描的癌症患者。视觉解释、肿瘤最大标准化摄取值（SUVmax）、肝脏SUVmax和肿瘤/肝脏SUVmax比值与CT、移位MRI检查结果和最终诊断（基于活检或临床/放射随访）相关。共发现109例肾上腺肿块，其中49例为恶性，60例为良性。肿瘤/肝脏SUVmax比值阈值为1.0比单独的SUVmax或视觉解释更准确地区分肿瘤类型。CT和移位MRI的诊断准确率（92 - 97%）与FDG PET/CT的诊断准确率（94 - 97%）相似。综上所述，FDG PET/CT能够准确表征肾上腺肿瘤，具有良好的敏感性和特异性。使用1.0作为肿瘤/肝脏SUVmax比值的阈值似乎有望区分癌症患者肾上腺肿块的良恶性。
The ability of integrated F-18-fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) to distinguish between benign and malignant incidental non-secreting adrenal masses was evaluated in cancer patients. Results were compared with those of CT and shift magnetic resonance imaging (MRI). A total of 1832 cancer patients who had undergone FDG PET/CT scans were retrospectively evaluated. Visual interpretation, tumour maximum standardized uptake value (SUVmax), liver SUVmax and tumour/liver SUVmax ratios were correlated with the findings of CT, shift MRI and final diagnosis (based on biopsy or clinical/radiological follow-up). A total of 109 adrenal masses were found: 49 were malignant and 60 were benign on final diagnosis. A tumour/liver SUVmax ratio threshold of 1.0 was more accurate in differentiating the tumour type than tumour SUVmax or visual interpretation alone. Diagnostic accuracy of CT and shift MRI (92 - 97%) was similar to that for FDG PET/CT (94 - 97%). In conclusion, FDG PET/CT accurately characterizes adrenal tumours, with excellent sensitivity and specificity. Use of 1.0 as the threshold for the tumour/liver SUVmax ratio seems to be promising for distinguishing benign from malignant adrenal masses in cancer patients.