Serum prolactin levels in sons of alcoholics and control subjects.
Serum prolactin levels in sons of alcoholics and control subjects.
复制标题
酗酒者的儿子和对照受试者的血清催乳素水平。
DOI：
10.1176/ajp.144.7.854
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Risch,C
中科院分区：
文献类型：
--
作者：
Schuckit,MA;Gold,E;Risch,C
作者评估了30名健康、饮酒、酗酒的年轻成年儿子和30名匹配的对照组受试者血清催乳素水平的变化，以此作为衡量对酒精反应的差异。对照组受试者在人口统计学变量、吸毒史和饮酒史方面进行了匹配。每个人都接受了三次测试，按随机顺序接受安慰剂、0.75毫升/公斤乙醇和1.1毫升/公斤乙醇。控制基线催乳素测量和安慰剂后的激素变化，作者发现，酗酒者的儿子在应对高剂量乙醇挑战时催乳素水平显著降低。
The authors evaluated changes in serum prolactin levels as a measure of differences in response to ethanol between 30 healthy, drinking, young adult sons of alcoholics and 30 matched control subjects with no family history of psychiatric or substance abuse problems. The control subjects were matched for demographic variables, drug use histories, and alcohol use histories. Each individual was tested on three occasions, receiving, in random order, placebo, 0.75 ml/kg of ethanol, and 1.1 ml/kg of ethanol. Controlling for baseline prolactin measures and hormonal changes after placebo, the authors found that the sons of alcoholics had significantly lower prolactin levels in response to the high-dose ethanol challenge.