Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration
Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration
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DOI：
10.1038/sj.bjp.0705912
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发表时间：
2004-09-01
影响因子：
7.3
通讯作者：
Serhan, CN
中科院分区：
文献类型：
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作者：
Bannenberg, G;Moussignac, RL;Serhan, CN
1脂氧素（LX）和阿司匹林触发的15-表-脂氧素（ATL）发挥有效的抗炎作用。在本研究中，我们测定了内源性LXA（4）和LXB 4、稳定的ATL类似物ATLa 2和一系列新的3-oxa-ATL类似物的抗炎功效（ZK-996、ZK-990、ZK-994和ZK-142）。2 LXA（4）、LXB 4、ATLa 2和ZK-994具有口服活性，在非常低的剂量下表现出对酵母聚糖A诱导的腹膜炎的有效全身抑制（50 ng kg（-1）- 50 mug kg（-1））。3静脉注射ZK-994和ZK-142（500 μ g/kg-1）可有效减轻后肢缺血/再灌注诱导的肺损伤，抑制率分别为32 ± 12和53 ± 5%（P
1 Lipoxins (LX) and aspirin-triggered 15-epi-lipoxins (ATL) exert potent anti-inflammatory actions. In the present study, we determined the anti-inflammatory efficacy of endogenous LXA(4) and LXB4, the stable ATL analog ATLa2, and a series of novel 3-oxa-ATL analogs (ZK-996, ZK-990, ZK-994, and ZK-142) after intravenous, oral, and topical administration in mice.2 LXA(4), LXB4, ATLa2, and ZK-994 were orally active, exhibiting potent systemic inhibition of zymosan A-induced peritonitis at very low doses (50 ng kg(-1) - 50 mug kg(-1)).3 Intravenous ZK-994 and ZK-142 (500 mug kg(-1)) potently attenuated hind limb ischemia/ reperfusion-induced lung injury, with 32 +/- 12 and 53 +/- 5% inhibition ( P