The role of influenza, RSV and other common respiratory viruses in severe acute respiratory infections and influenza-like illness in a population with a high HIV sero-prevalence, South Africa 2012-2015
The role of influenza, RSV and other common respiratory viruses in severe acute respiratory infections and influenza-like illness in a population with a high HIV sero-prevalence, South Africa 2012-2015
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DOI：
10.1016/j.jcv.2015.12.004
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发表时间：
2016-02-01
影响因子：
8.8
通讯作者：
Venter, Marietjie
中科院分区：
文献类型：
--
作者：
Pretorius, Marthi A.;Tempia, Stefano;Venter, Marietjie
背景：在急性呼吸道感染患者中检测到的病毒可能是导致疾病或无症状排毒的原因。目的：估计每种不同呼吸道病毒的归因分数 (AF) 和疾病的检出率研究设计：我们比较了 10 种常见呼吸道病毒（甲型和乙型流感病毒、副流感病毒 1-3、呼吸道合胞病毒 (RSV)、腺病毒、鼻病毒、人2012-2015 年南非因严重急性呼吸道疾病 (SARI) 住院的 HIV 阳性和阴性患者、患有流感样疾病 (ILI) 的门诊患者以及未报告任何发热、呼吸道或胃肠道疾病的对照受试者中检测偏肺病毒 (hMPV) 和肠道病毒）。结果：我们纳入了 1959 名 SARI、3784 名 ILI 和 1793 名对照，其 HIV 血清流行率为分别为 26%、30% 和 43%。流感病毒（AF：86.3%；95%CI：77.7-91.6%）、hMPV（AF：85.6%；95%CI：72.0-92.6%）和RSV（AF：83.7%；95%CI：77.5-88.2%）感染与严重疾病相关，而鼻病毒（AF： 46.9%；95%CI：37.6-56.5%）和腺病毒（AF：36.4%；95%CI：20.6-49.0%）仅中度相关。结论：如果在 ILI 和 SARI 中检测到，流感、RSV 和 hMPV 可被视为病原体，而鼻病毒和腺病毒通常在对照中发现，表明它们可能仅导致阳性病例中观察到的一部分临床疾病。患者。尽管如此，它们可能是疾病的重要促成因素。 (C) 2015 Elsevier B.V. 保留所有权利。
Background: Viruses detected in patients with acute respiratory infections may be the cause of illness or asymptomatic shedding.Objective: To estimate the attributable fraction (AF) and the detection rate attributable to illness for each of the different respiratory virusesStudy design: We compared the prevalence of 10 common respiratory viruses (influenza A and B viruses, parainfluenza virus 1-3; respiratory syncytial virus (RSV); adenovirus, rhinovirus, human metapneumovirus (hMPV) and enterovirus) in both HIV positive and negative patients hospitalized with severe acute respiratory illness (SARI), outpatients with influenza-like illness (ILI), and control subjects who did not report any febrile, respiratory or gastrointestinal illness during 2012-2015 in South Africa.Results: We enrolled 1959 SARI, 3784 ILI and 1793 controls with a HIV sero-prevalence of 26%, 30% and 43%, respectively. Influenza virus (AF: 86.3%; 95%CI: 77.7-91.6%), hMPV (AF: 85.6%; 95%CI: 72.0-92.6%), and RSV (AF: 83.7%; 95%CI: 77.5-88.2%) infections were associated with severe disease., while rhinovirus (AF: 46.9%; 95%CI: 37.6-56.5%) and adenovirus (AF: 36.4%; 95%CI: 20.6-49.0%) were only moderately associated.Conclusions: Influenza, RSV and hMPV can be considered pathogens if detected in ILI and SARI while rhinovirus and adenovirus were commonly identified in controls suggesting that they may cause only a proportion of clinical disease observed in positive patients. Nonetheless, they may be important contributors to disease. (C) 2015 Elsevier B.V. All rights reserved.