Induction of muscarinic cholinergic responsiveness inXenopus oocytes by mRNA isolated from rat brain
Induction of muscarinic cholinergic responsiveness inXenopus oocytes by mRNA isolated from rat brain
复制标题
通过从大鼠脑中分离的 mRNA 诱导非洲爪蟾卵母细胞的毒蕈碱胆碱能反应性
DOI：
10.1016/0006-8993(85)90166-0
复制
发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
C. Hirono
中科院分区：
文献类型：
--
作者：
H. Sugiyama;Y. Hisanaga;C. Hirono
Microinjection of mRNA from adult rat brains intoXenopusoocytes induced an electrophysiological response to acetylcholine in the cells. The cells responded to acetylcholine through muscarinic receptors which appeared on the cell surface after microinjection of the mRNA and showed the depolarization, mainly due to an increase in membrane permeability to Cl ions. The acetylcholine reaction did not require extracellular Ca ions and was suppressed by pertussis toxin, suggesting the involvement of the inhibitory guanine nucleotide-binding regulatory protein.
激动剂将抑制环 AMP 形成的毒蕈碱受体与刺激磷酸肌醇代谢的毒蕈碱受体区分开来。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Brown,JH;Brown,SL
通讯作者：
Brown,SL