Genotypes and phylogenetic analysis of adenovirus in children with respiratory infection in Buenos Aires, Argentina (2000-2018).
Genotypes and phylogenetic analysis of adenovirus in children with respiratory infection in Buenos Aires, Argentina (2000-2018).
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阿根廷布宜诺斯艾利斯儿童呼吸道感染中腺病毒的基因分型和系统发育分析(2000-2018)
DOI：
10.1371/journal.pone.0248191
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Echavarria M
中科院分区：
文献类型：
--
作者：
Marcone DN;Culasso ACA;Reyes N;Kajon A;Viale D;Campos RH;Carballal G;Echavarria M
Human adenoviruses (HAdV) are one of the most frequent causes of respiratory infections around the world, causing mild to severe disease. In Argentina, many studies focused on the association of HAdV respiratory infection with severe disease and fatal outcomes leading to the discovery in 1984 of a genomic variant 7h associated with high fatality. Although several molecular studies reported the presence of at least 4 HAdV species (B, C, D and E) in Argentina, few sequences were available in the databases. In this study, sequences from the hexon gene region were obtained from 141 patients as a first approach to assess the genetic diversity of HAdVs circulating in Buenos Aires, Argentina. Phylogenetic analysis of these sequences and others recovered from public databases confirmed the circulation of the four above-mentioned species represented by 11 genotypes, with predominance in species B and C and shifts in their proportion in the studied period (2000 to 2018). The variants detected in Argentina, for most of the genotypes, were similar to those already described in other countries. However, uncommon lineages belonging to genotypes C2, C5 and E4 were detected, which might indicate the circulation of local variants and will deserve further studies of whole-genome sequences.
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影响因子：
9.4
作者：
Echavarria, M;Maldonado, D;Carballal, G
通讯作者：
Carballal, G
DOI：
10.1016/j.jcv.2018.04.012
发表时间：
2018-07
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Barnadas C;Schmidt DJ;Fischer TK;Fonager J
通讯作者：
Fonager J
影响因子：
3.7
作者：
Liu C;Xiao Y;Zhang J;Ren L;Li J;Xie Z;Xu B;Yang Y;Qian S;Wang J;Shen K
通讯作者：
Shen K
影响因子：
9.4
作者：
Kajon, Adriana E.;Dickson, Laura M.;Echavarria, Marcela
通讯作者：
Echavarria, Marcela
影响因子：
3.7
作者：
Kajon, AE;Wadell, G
通讯作者：
Wadell, G