Failure of short-course ceftriaxone chemotherapy for multidrug-resistant typhoid fever in children: a randomized controlled trial in Pakistan
Failure of short-course ceftriaxone chemotherapy for multidrug-resistant typhoid fever in children: a randomized controlled trial in Pakistan
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DOI：
10.1128/aac.44.2.450-452.2000
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发表时间：
2000-02-01
影响因子：
4.9
通讯作者：
Shadmani, M
中科院分区：
文献类型：
--
作者：
Bhutta, ZA;Khan, IA;Shadmani, M
多药耐药（MDR）伤寒与广谱头孢菌素治疗的确切持续时间是不确定的。我们前瞻性地将57名培养证实为MDR伤寒的儿童随机分为两组，分别接受静脉注射头孢曲松（CRO）（65 mg/kg体重/天）7天（短程; n = 29）或14天（常规; n = 28）。通过伤寒发病率评分和细菌学清除率的系列监测评价，两组间对治疗的反应相当。与常规治疗相比，14%接受CRO治疗7天的儿童在停止治疗后4周内确认细菌学复发。
The precise duration of therapy of multidrug-resistant (MDR) typhoid with broad-spectrum cephalosporins is uncertain. We prospectively randomized 57 children with culture-proven MDR typhoid to receive treatment with intravenous ceftriaxone (CRO) (65 mg/kg of body weight/day) for 7 days (short course; n = 29) or 14 days (conventional; n = 28). The response to therapy, as evaluated by the serial monitoring of the typhoid morbidity score and bacteriological clearance, was comparable between groups. In contrast to the conventional therapy, 14% of the children receiving CRO for 7 days had a confirmed bacteriological relapse within 4 weeks of stopping therapy.