Estimating the effects of energy imbalance on changes in body weight in children
Estimating the effects of energy imbalance on changes in body weight in children
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DOI：
10.1093/ajcn/83.4.859
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发表时间：
2006-04-01
影响因子：
7.1
通讯作者：
Ravussin, E
中科院分区：
文献类型：
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作者：
Swinburn, BA;Jolle, D;Ravussin, E
背景资料：从能量平衡的变化中估计体重的变化对于预测肥胖预防干预措施的效果是重要的。目的：目的是开发和验证一个方程，用于预测总能量摄入（TEI）或总能量消耗（TEE）变化对儿童平均体重的影响。设计：在963名平均（+/- SD）年龄为8.1 ± 2.8岁（范围：4-18岁）、体重为31.5 ± 17.6 kg的儿童中，使用双标记水测量TEE。在以身高、年龄和性别作为协变量的线性回归模型中分析对数体重（因变量）和对数TEE（自变量）。假设动态平衡点（称为“稳定点”）发生在能量平衡（TEE = TEI）、体重稳定（忽略生长）和能量通量（EnFlux）等于TEE.Results的人群中，TEE（或EnFlux）解释了体重方差的74%。纳入协变量后，非标准化回归系数为0.45（95% CI：0.38，0.51; R-2 = 0.86）。转换成比例机会（时间，对时间，）给出等式（重量（2）/重量（1））=（EnFlux（2）/EnFlux（1））（0-45）。在3项纵向研究中（n = 212;平均随访3.4年），该方程预测平均随访测量体重在0.5%以内。结论：EnFlux与体重呈正相关，这意味着高TEI（而不是低体力活动和低TEE）是高体重的主要决定因素。平均EnFlux差异为10%的两个儿童人群的平均体重差异为4.5%。
Background: Estimating changes in weight from changes in energy balance is important for predicting the effect of obesity prevention interventions.Objective: The objective was to develop and validate an equation for predicting the mean weight of a population of children in response to a change in total energy intake (TEI) or total energy expenditure (TEE).Design: In 963 children with a mean (+/- SD) age of 8.1 +/- 2.8 y (range: 4-18 y) and weight of 31.5 +/- 17.6 kg, TEE was measured by using doubly labeled water. Log weight (dependent variable) and log TEE (independent variable) were analyzed in a linear regression model with height, age, and sex as covariates. It was assumed that points of dynamic balance, called "settling points," occur for populations wherein energy is in balance (TEE = TEI), weight is stable (ignoring growth), and energy flux (EnFlux) equals TEE.Results: TEE (or EnFlux) explained 74% of the variance in weight. The unstandardized regression coefficient was 0.45 (95% CI: 0.38, 0.51; R-2 = 0.86) after including covariates. Conversion into proportional chances (time, to time,) gave the equation (weight(2)/weight(1)) = (EnFlux(2)/EnFlux(1))(0-45). In 3 longitudinal studies (n = 212; mean follow-up of 3.4 y), the equation predicted the mean follow-up measured weight to within 0.5%.Conclusions: The relation of EnFlux with weight was positive, which implied that a high TEI (rather than low physical activity and low TEE) was the main determinant of high body weight. Two populations of children with a 10% difference in mean EnFlux Would have a 4.5% difference in mean weight.