ANTI-NUCLEIC ACID ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS AND THEIR FAMILIES - INCIDENCE AND CORRELATION WITH LYMPHOCYTOTOXIC ANTIBODIES
ANTI-NUCLEIC ACID ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS AND THEIR FAMILIES - INCIDENCE AND CORRELATION WITH LYMPHOCYTOTOXIC ANTIBODIES
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DOI：
10.1172/jci108190
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发表时间：
1975-01-01
影响因子：
15.9
通讯作者：
TALAL, N
中科院分区：
文献类型：
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作者：
DEHORATIUS, RJ;PILLARISETTY, R;TALAL, N
在28例系统性红斑狼疮（SLE）先证者中，抗RNA抗体阳性率为82%，在124例SLE家系成员中，抗RNA抗体阳性率为16%。对照组76例，发病率仅为5%。在SLE家族成员中，仅在94名先证者的密切家庭接触者中发现了21%的抗体。SLE先证者抗天然DNA（nDNA）抗体的发生率为68%。先证者家庭密切接触者中抗nDNA抗体的发生率为6%，与对照家庭中的1%发生率无显著差异。淋巴细胞毒性抗体发生在57%的SLE家庭成员作为一个整体，在68%的密切家庭接触。在SLE先证者中，淋巴细胞毒性抗体与抗单链RNA（poly A）和抗nDNA相关，但与抗双链RNA（poly A-poly U）无关。另一方面，在家庭接触者的淋巴细胞毒性抗体与抗双链RNA（聚腺苷酸-聚U），但不与抗聚腺苷酸或抗nDNA。抗RNA抗体存在于近亲家庭接触者中，但不存在于非近亲家庭接触者中。这些发现加强了环境因子（可能是病毒）和遗传反应在SLE发病机制中都很重要的假设。因此，家庭成员可能是一个合乎逻辑的人群，在其中寻找特异性抗体的病毒剂。
Anti-RNA antibodies were found in 82% of 28 systemic lupus erythematosus (SLE) probands and in 16% of 124 of their family members. The incidence in 76 control family members was only 5%. In the SLE family members, the antibodies were found exclusively in 21% of the 94 close household contacts of the probands. The incidence of anti-native DNA (nDNA) antibodies was 68% for the SLE probands. The incidence of anti-nDNA antibodies in close household contacts of the probands was 6%, which was not significantly different from the 1% incidence found in control families. Lymphocytotoxic antibodies occurred in 57% of the SLE family members as a whole and in 68% of the close household contacts. In the SLE probands, lymphocytotoxic antibodies correlated with anti-single-stranded RNA (poly A) and anti-nDNA but not with anti-double-stranded RNA (poly A-poly U). On the other hand, lymphocytotoxic antibodies in the household contacts correlated with anti-double-stranded RNA (poly A-poly U) but not with anti-poly A or anti-nDNA. The anti-RNA antibodies were present in consanguineous household contacts but not in nonconsanguineous household contacts. These findings strengthen the hypothesis that both an environmental agent, possibly a virus, as well as the genetic response are important in the pathogenesis of SLE. Family members may therefore be a logical population in whom to search for specific antibodies to a viral agent.