Influence of Brain-Derived Neurotrophic Factor Genetic Polymorphisms on the Ages of Onset for Heroin Dependence in a Chinese Population
Influence of Brain-Derived Neurotrophic Factor Genetic Polymorphisms on the Ages of Onset for Heroin Dependence in a Chinese Population
复制标题
脑源性神经营养因子基因多态性对中国人群海洛因依赖发病年龄的影响
DOI：
10.1089/gtmb.2012.0016
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发表时间：
2012-09-01
影响因子：
1.4
通讯作者：
Wang, Wei
中科院分区：
文献类型：
--
作者：
Meng, Chao;Lan, Jie;Wang, Wei
目的：本研究旨在探讨脑源性神经营养因子（BDNF）基因多态性与海洛因依赖的关系。对486例海洛因依赖患者和226例健康对照者的BDNF基因的3个多态性位点（rs10835210、rs16917234和rs6265）进行基因分型，分析这些多态性与海洛因依赖发病年龄的相关性。我们将健康病例定义为“未知表型”，并使用内表型（行为特征）对海洛因依赖组进行分层，基于自我报告的特征，以检查BDNF多态性（rs10835210，rs16917234和rs6265）与海洛因依赖之间的关联。结果：BDNF基因多态性的等位基因分布在海洛因依赖者和对照组之间没有显著差异。然而，我们发现，在控制了rs6265基因型之间的行为特征之后，BDNF rs6265的AA携带者比GG携带者更早地出现海洛因依赖，并且具有更明显的海洛因依赖家族史倾向。结论：提示BDNF基因多态性（rs6265）可能影响海洛因依赖的发病年龄。BDNF基因可能导致海洛因依赖的脆弱性。
Aim: The study aims at evaluating the association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and heroin-dependent patients in the Chinese population. Three polymorphisms of the BDNF-gene (rs10835210, rs16917234, and rs6265) in 486 heroin-dependent patients and in 226 healthy controls were genotyped for analyzing the association of these polymorphisms with age of onset of heroin dependence. We defined the healthy cases as "unknown phenotype" and used the endophenotype (behavior traits) to stratify the heroin dependents group on the basis of self-reporting traits for examining the association between BDNF polymorphisms (rs10835210, rs16917234, and rs6265) and heroin dependence. Results: Allelic distributions of BDNF gene polymorphisms did not differ significantly between heroin-dependent patients and controls. However, we found that the AA carriers of BDNF rs6265 had an earlier onset of heroin dependence and a clearer tendency of family history of heroin-dependent than GG carriers after controlling behavior characteristics across rs6265 genotypes. Conclusions: Our findings suggested that the BDNF genetic polymorphism (rs6265) may have effects on the age of onset of heroin dependence among the Chinese population. The BDNF gene could contribute to vulnerabilities to heroin dependence.