Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant.
Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant.
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DOI：
10.1038/s41586-022-04462-1
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
Sato K
中科院分区：
文献类型：
--
作者：
Suzuki R;Yamasoba D;Kimura I;Wang L;Kishimoto M;Ito J;Morioka Y;Nao N;Nasser H;Uriu K;Kosugi Y;Tsuda M;Orba Y;Sasaki M;Shimizu R;Kawabata R;Yoshimatsu K;Asakura H;Nagashima M;Sadamasu K;Yoshimura K;Genotype to Phenotype Japan (G2P-Japan) Consortium;Sawa H;Ikeda T;Irie T;Matsuno K;Tanaka S;Fukuhara T;Sato K
SARS-CoV-2的Omicron变体的出现是一个紧迫的全球健康问题。在这项研究中，我们的统计模型表明，Omicron在包括南非在内的几个国家的传播速度比Delta变体更快。细胞培养实验表明，Omicron的融合性低于Delta和SARS-CoV-2的祖先菌株。尽管Delta的刺突（S）蛋白被有效地切割成两个亚基，这有利于细胞-细胞融合，但与Delta和祖先SARS-CoV-2的S蛋白相比，Omicron S蛋白被切割的效率较低。此外，在仓鼠模型中，Omicron显示出较低的肺感染性，并且与Delta和祖先SARS-CoV-2相比，其致病性较低。我们的多尺度研究揭示了Omicron的病毒学特征，包括在人群中快速生长，较低的融合性和减弱的致病性。在人类细胞系中的体外研究和在仓鼠模型中的体内研究表明，SARS-CoV-2 Omicron变异株的致病性低于Delta变异株和SARS-CoV-2的祖先株。
The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern. In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several countries including South Africa. Cell culture experiments showed Omicron to be less fusogenic than Delta and than an ancestral strain of SARS-CoV-2. Although the spike (S) protein of Delta is efficiently cleaved into two subunits, which facilitates cell–cell fusion, the Omicron S protein was less efficiently cleaved compared to the S proteins of Delta and ancestral SARS-CoV-2. Furthermore, in a hamster model, Omicron showed decreased lung infectivity and was less pathogenic compared to Delta and ancestral SARS-CoV-2. Our multiscale investigations reveal the virological characteristics of Omicron, including rapid growth in the human population, lower fusogenicity and attenuated pathogenicity. In vitro studies in human cell lines and in vivo studies in a hamster model show that the SARS-CoV-2 Omicron variant is less pathogenic than both the Delta variant and an ancestral strain of SARS-CoV-2.
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DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
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Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
影响因子：
64.5
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影响因子：
1.2
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通讯作者：
Ruden, Douglas M.
影响因子：
64.8
作者：
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通讯作者：
Gupta RK
影响因子：
64.8
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通讯作者：
Gupta RK