Approximations to profile score distributions.
Approximations to profile score distributions.
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DOI:
10.1089/cmb.1994.1.93
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发表时间:
1994-01-01
期刊:
影响因子:
--
通讯作者:
Waterman, M S
中科院分区:
文献类型:
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作者:
Goldstein, L;Waterman, M S
Profiles, which are summaries of multiple alignments of a sequence family, are used to find new instances of the family in databases. In this paper, we study the maximum score M obtained when the profile is aligned without indels at all possible positions of a random sequence. The main theorem gives an approximation to the distribution function of M with an explicit bound on the error. This theorem implies that M has a limiting extreme value distribution.