Why do people with rheumatoid arthritis still die prematurely?
Why do people with rheumatoid arthritis still die prematurely?
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DOI：
10.1136/ard.2008.098038
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发表时间：
2008-12-01
影响因子：
27.4
通讯作者：
Gabriel, S. E.
中科院分区：
文献类型：
--
作者：
Gabriel, S. E.
早死一直被认为是类风湿关节炎（RA）的一种表现。有三条证据可以解释为什么类风湿关节炎患者过早死亡，以及为什么类风湿关节炎患者和普通人群之间的死亡率差距似乎在扩大。首先，类风湿关节炎患者有几个严重的并发症的风险较高，他们往往会经历更糟糕的结果后，这些疾病的发生。其次，类风湿关节炎患者似乎没有得到最佳的初级或二级预防保健。第三，与RA相关的全身炎症和免疫功能障碍似乎促进和加速了合并症和死亡率。本文提供了一个简短的总结和解释这些发现的数据基础。总之，这些结果提供了一个令人信服的论据，支持一个专门针对消除类风湿关节炎患者过早死亡的集中研究计划。
Premature death has been long recognised as a manifestation of rheumatoid arthritis (RA). Three lines of evidence can explain why patients with RA die prematurely and why the mortality gap between patients with RA and the general population appears to widening. First, patients with RA have a higher risk of several serious comorbid conditions and they tend to experience worse outcomes after the occurrence of these illnesses. Second, patients with RA do not appear to receive optimal primary or secondary preventive care. And third, the systemic inflammation and immune dysfunction associated with RA appears to promote and accelerate comorbidity and mortality. This paper provides a brief summary and interpretation of the data underlying these findings. Together, these results provide a compelling argument in favour of a focused research programme aimed specifically at eliminating premature death in patients with RA.