Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.
Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.
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DOI：
10.2147/cmar.s57846
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发表时间：
2014
影响因子：
3.3
通讯作者：
Goidts V
中科院分区：
文献类型：
--
作者：
Nakata S;Phillips E;Goidts V
癌症干细胞的概念在过去的几十年中获得了相当大的兴趣，部分原因是它们在治疗抗性中的潜在意义。然而，缺乏这些细胞的特异性细胞表面标志物阻碍了它们的分离，使得这种细胞亚群的表征在技术上具有挑战性。最近的研究表明，富含亮氨酸重复的G蛋白偶联受体4和5（LGR 4和LGR 5）在多个器官中的表达可能代表了成体干细胞的全球标志物。本文就LGR 4和LGR 5作为肿瘤干细胞标志物及其在肿瘤发生发展中的作用作一综述。
The concept of cancer stem cells has gained considerable interest in the last few decades, partly because of their potential implication in therapy resistance. However, the lack of specific cellular surface markers for these cells has impeded their isolation, making the characterization of this cellular subpopulation technically challenging. Recent studies have indicated that leucine-rich repeat-containing G-protein-coupled receptor 4 and 5 (LGR4 and LGR5) expression in multiple organs may represent a global marker of adult stem cells. This review aims to give an overview of LGR4 and LGR5 as cancer stem cell markers and their function in development.