Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus
Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus
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DOI：
10.1006/geno.2000.6138
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发表时间：
2000-04-01
期刊：
影响因子：
4.4
通讯作者：
Davies, KE
中科院分区：
文献类型：
--
作者：
Rodrigues, NR;Theodosiou, AM;Davies, KE
我们已经确定Ngef为Dbl基因家族的新成员。该家族的许多成员已被证明作为Rho型GTP酶的鸟嘌呤核苷酸交换因子发挥作用。Ngef主要在大脑中表达，在尾状核中信号最强，尾状核是一个与运动控制相关的区域。Ngef含有一个翻译的三核苷酸重复序列，一个被甘氨酸中断的聚谷氨酸片段。我们已经将Ngef基因定位于小鼠1号染色体，将Ngef的人类同源物定位于人类2q37。我们已经在初步实验中表明，Ngef在细胞培养中具有转化潜力，并且能够在裸鼠中诱导肿瘤。(C)北京大学出版社.
We have identified Ngef as a novel member of the family of Dbl genes. Many members of this family have been shown to function as guanine nucleotide exchange factors for the Rho-type GTPases. Ngef is predominantly expressed in brain, with the strongest signal in the caudate nucleus, a region associated with the control of movement. Ngef contains a translated trinucleotide repeat, a polyglutamic acid stretch interrupted by a glycine, We have localized the Ngef gene to mouse chromosome 1 and the human homologue of Ngef to human chromosome 2q37. We have shown in preliminary experiments that Ngef has transforming potential in cell culture and is able to induce tumors in nude mice. (C) 2000 Academic Press.