Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study
Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study
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DOI：
10.1503/cmaj.090040
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发表时间：
2009-08-04
影响因子：
14.6
通讯作者：
Gussekloo, Jacobijn
中科院分区：
文献类型：
--
作者：
den Elzen, Wendy P. J.;Willems, Jorien M.;Gussekloo, Jacobijn
背景：关于贫血和合并症对老年功能状态和死亡率的可归因影响的研究有限。方法：Leiden 85-plus研究是一项基于人群的前瞻性随访研究，研究对象为562名85岁的老年人。贫血是根据世界卫生组织的标准定义的。我们在基线和之后的5年中每年测量3个功能状态参数：日常生活的基本和辅助活动的残疾，认知功能和抑郁症状的存在。我们从市政登记处获得了死亡率数据。结果：基线时贫血患病率为26.7%（150/562）。基线时贫血的参与者比基线时无贫血的参与者有更多的日常生活活动障碍、更差的认知功能和更多的抑郁症状
Background: There is limited insight into the attributable effect of anemia and comorbidity on functional status and mortality in old age.Methods: The Leiden 85-plus Study is a population-based prospective follow-up study of 562 people aged 85 years. Anemia was defined according to World Health Organization criteria. We measured 3 parameters of functional status at baseline and annually thereafter for 5 years: disability in basic and instrumental activities of daily living, cognitive function and the presence of depressive symptoms. We obtained mortality data from the municipal registry.Results: The prevalence of anemia at baseline was 26.7% (150/562). Participants who had anemia at baseline had more disability in activities of daily living, worse cognitive function and more depressive symptoms than participants without anemia at baseline (p