Of mice and Myc: c-Myc and mammary tumorigenesis
Of mice and Myc: c-Myc and mammary tumorigenesis
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DOI：
10.1023/b:jomg.0000023586.69263.0b
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发表时间：
2004-01-01
影响因子：
2.5
通讯作者：
Dickson, RB
中科院分区：
文献类型：
--
作者：
Jamerson, MH;Johnson, MD;Dickson, RB
原癌基因c-myc参与调节增殖和凋亡，其通过基因组和后基因组机制的失调有助于多种人类癌症的发展和进展，包括乳腺癌。c-Myc的表达失调也通过改变细胞分化途径和通过诱导基因组不稳定性促进诱变而促进肿瘤转化。转基因和基因敲除小鼠常用于解决特定基因影响恶性肿瘤发生和发展的机制。在这篇综述中，我们讨论了如何从各种c-myc转基因乳腺肿瘤模型中获得的研究结果有助于提高我们的分辨率c-Myc的作用，无论是在肿瘤发生的小鼠乳腺癌和人类乳腺癌。
The proto-oncogene c-myc is involved in regulating proliferation and apoptosis, and its deregulation via genomic and postgenomic mechanisms, contributes to the development and progression of multiple human cancers, including those of the breast. Deregulated expression of c-Myc also contributes to neoplastic transformation by altering cellular differentiation pathways and by facilitating mutagenesis through induction of genomic instability. Transgenic and gene-knockout mice are frequently utilized to resolve the mechanisms through which specific genes influence the development and progression of malignancies. In this review, we discuss how research findings obtained from various c-myc transgenic mammary tumor models help to improve our resolution of c-Myc's role both in tumorigenesis of the murine mammary gland and cancer of the human breast.