QUANTITATIVE-ANALYSIS OF COLLAGEN AND COLLAGEN SUBTYPE-I, SUBTYPE-III, AND SUBTYPE-V IN HUMAN PANCREATIC-CANCER, TUMOR-ASSOCIATED CHRONIC-PANCREATITIS, AND ALCOHOLIC CHRONIC-PANCREATITIS

QUANTITATIVE-ANALYSIS OF COLLAGEN AND COLLAGEN SUBTYPE-I, SUBTYPE-III, AND SUBTYPE-V IN HUMAN PANCREATIC-CANCER, TUMOR-ASSOCIATED CHRONIC-PANCREATITIS, AND ALCOHOLIC CHRONIC-PANCREATITIS
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DOI：
10.1097/00006676-199511000-00007
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发表时间：
1995-11-01
期刊：
PANCREAS
影响因子：
2.9
通讯作者：
IMAMURA, M
IMAMURA, M
中科院分区：
医学4区
文献类型：
--
作者：
IMAMURA, T;IGUCHI, H;IMAMURA, M

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通过测定14例胰腺癌患者的4-羟脯氨酸含量，测定人胰腺癌组织、肿瘤相关慢性胰腺炎（TACP）组织和正常胰腺组织中胶原蛋白的含量。还对四名酒精性慢性胰腺炎（AlCP）患者进行了分析。胰腺癌组织和 TACP 组织中的平均胶原蛋白含量大约是正常胰腺组织的三倍，使用离子交换柱和凝胶渗透柱的高效液相色谱对来自八名患者的胰腺浸润性导管癌组织和 TACP 组织中的 I、III 和 V 型胶原蛋白的溴化氰肽进行了连续分析。胰腺癌组织和TACP组织之间未检测到I型、III型和V型胶原蛋白的比例存在差异。 AlCP组织中的平均胶原蛋白含量显着低于TACP组织中的平均胶原蛋白含量，但在这两种组织之间检测到I型、III型和V型胶原蛋白的比例没有差异。这些结果表明，人类胰腺癌和 TACP 中纤维状胶原的数量和分布模式相似。
The collagen content in human pancreatic cancer tissue, tissue of tumor-associated chronic pancreatitis (TACP), and normal pancreatic tissue was determined in 14 patients with pancreatic cancer by measuring the amount of 4-hydroxyproline. Four patients with alcoholic chronic pancreatitis (AlCP) were also analyzed. The mean collagen content in both pancreatic cancer tissue and TACP tissue was approximately threefold higher than in normal pancreatic tissue, Cyanogen bromide peptides of type I, III, and V collagens from invasive ductal carcinomatous tissue of the pancreas and from TACP tissue of eight patients were analyzed sequentially using high-performance liquid chromatography with ion-exchange and gel-permeation columns. No difference in the proportion of type I, III, and V collagens was detected between pancreatic cancer tissue and TACP tissue. The mean collagen content in AlCP tissue was significantly lower than that in TACP tissue, but no difference in the proportion of type I, III, and V collagens was detected between these two tissues. These results indicate a similar quantity and distribution pattern of fibrillar collagen in human pancreatic cancer and TACP.