Body-composition changes in the simian immunodeficiency virus-infected juvenile rhesus macaque
Body-composition changes in the simian immunodeficiency virus-infected juvenile rhesus macaque
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DOI：
10.1086/386290
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发表时间：
2004-06-01
影响因子：
6.4
通讯作者：
Gorbach, SL
中科院分区：
文献类型：
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作者：
Freeman, LM;Mansfield, KG;Gorbach, SL
背景。身体成分的变化在感染人类免疫缺陷病毒的个体中很常见。本研究的目的是测量感染猿猴免疫缺陷病毒（SIV）的猕猴体内纵向身体成分的变化，作为获得性免疫缺陷综合症（艾滋病）消瘦的模型。方法。十二只幼年猕猴接种了 SIVmac239。前瞻性地每 4 周进行一次免疫学、病毒学、体格测量和双能 X 射线吸收测量，持续 72 周，并与 8 只未感染的对照猕猴的测量结果进行比较。在前 4 周内，感染 SIV 的猕猴的体脂百分比下降，而瘦组织百分比则增加；在第 4-72 周期间，这些猕猴比未感染的对照猕猴损失了更大比例的总脂肪组织，但皮下脂肪沉积更多。就在死亡之前，与幸存的 SIV 感染猕猴 (n = 5) 相比，死亡的 SIV 感染猕猴 (n = 7) 的体重指数、腹部脂肪、脂肪组织和瘦肉组织损失更大。结论。感染 SIV 的幼年猕猴的身体成分变化表现出 3 个阶段：急性感染期间，脂肪组织体重减轻；猕猴生长的补偿期，但生长速度有所降低；以及终末期，在此期间所有身体部位的组织都会丢失。感染 SIV 的幼年猕猴为研究艾滋病消瘦，特别是儿童艾滋病消瘦提供了一个有用的模型。
Background. Body-composition changes are common in individuals infected with human immunodeficiency virus. The purpose of the present study was to measure, as a model of wasting in acquired immunodeficiency syndrome (AIDS), longitudinal body-composition changes in macaques infected with simian immunodeficiency virus (SIV).Methods. Twelve juvenile macaques were inoculated with SIVmac239. Immunologic, virologic, somatometric, and dual-energy x-ray-absorptiometry measurements were performed prospectively every 4 weeks for 72 weeks and were compared to measurements taken from 8 uninfected control macaques.Results. During the first 4 weeks, body-fat percentage decreased in the SIV-infected macaques while lean-tissue percentage increased; during weeks 4-72, these macaques lost a greater percentage of total fat tissue but had more subcutaneous-fat deposition than did the uninfected control macaques. Just prior to death, the SIV-infected macaques that died (n = 7) had a greater loss in body-mass index, abdominal fat, fat tissue, and lean tissue, compared with that in SIV-infected macaques that survived (n = 5).Conclusions. Body-composition changes in SIV-infected juvenile macaques exhibit 3 phases: during acute infection, loss of body weight from fat tissue; a compensation period during which macaques grow, but at a reduced rate; and a terminal phase, during which tissue is lost from all body compartments. The SIV-infected juvenile macaque provides a useful model for the investigation of wasting in AIDS, particularly for pediatric AIDS wasting.