Usefulness of Demarcation of Differentiated-Type Early Gastric Cancers after Helicobacter pylori Eradication by Magnifying Endoscopy with Narrow-Band Imaging
Usefulness of Demarcation of Differentiated-Type Early Gastric Cancers after Helicobacter pylori Eradication by Magnifying Endoscopy with Narrow-Band Imaging
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DOI：
10.1159/000489167
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发表时间：
2018-01-01
期刊：
影响因子：
3.2
通讯作者：
Nagahara, Akihito
中科院分区：
文献类型：
--
作者：
Akazawa, Yoichi;Ueyama, Hiroya;Nagahara, Akihito
背景/目的：幽门螺杆菌（Hp）根除后的早期胃癌很难界定。我们使用血管加表面分类系统（VSCS），以确定放大内镜窄带成像（ME-NBI）是否可以划分幽门螺杆菌根除后的分化型早期胃癌，并确定不明确的分界线（DL）的原因。研究方法：对100例经内镜切除的分化型早期胃癌进行回顾性比较，其中Hp根除组34例，Hp感染组66例。临床病理因素和ME-NBI的结果，包括DL的存在或不存在，进行了检查。组织学、组织学胃炎、肿瘤边缘的表面结构、具有低级别淋巴结的高分化腺癌（tub 1-low）以及肿瘤表面和肿瘤边缘的非肿瘤上皮（NE）覆盖率进行了评价。结果：Hp根除组DL（-）发生率（11.8%，4/34）高于Hp感染组（1.5%，1/66）（p < 0.05）。Hp根除组的NE覆盖率高于Hp感染组（p < 0.05）。DL（-）例肿瘤边缘tub 1低或NE。结论：ME-NBI联合VSCS可检出绝大多数（88.2%）Hp根除后分化型早期胃癌的DL。(C)2018 S. Karger AG，巴塞尔
Background/Aims: Early gastric cancer after Helicobacter pylori (Hp) eradication is difficult to demarcate. We used the vessel plus surface classification system (VSCS) to determine whether magnifying endoscopy with narrow-band imaging (ME-NBI) could demarcate differentiated-type early gastric cancers after Hp eradication, and to identify causes of an unclear demarcation line (DL). Methods: Among 100 lesions of differentiated-type early gastric cancer resected endoscopically, 34 lesions in the Hp-eradicated group and 66 in the Hp-infected group were retrospectively compared. Clinicopathological factors and ME-NBI findings, including the presence or absence of the DL, were examined. Histopathologically, histological gastritis, the surface structure at the tumor border, well-differentiated adenocarcinoma with low-grade atypia (tub1-low), and non-neoplastic epithelium (NE) coverage rate on the tumor surface and at the tumor border were evaluated. Results: DL (-) cases were more frequent in the Hp-eradicated group (11.8%, 4/34) than in the Hp-infected group (1.5%, 1/66; p < 0.05). The Hp-eradicated group had a higher NE coverage rate than the Hp-infected group (p < 0.05). All DL (-) cases had tub1-low or NE at the tumor border. Conclusion: ME-NBI with VSCS can identify the DL in most patients (88.2%) with differentiated-type early gastric cancer after Hp eradication. (C) 2018 S. Karger AG, Basel