HORMONE BINDING ALTERS THE CONFORMATION OF THE INSULIN-RECEPTOR
HORMONE BINDING ALTERS THE CONFORMATION OF THE INSULIN-RECEPTOR
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DOI：
10.1126/science.7003712
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
CZECH, MP
中科院分区：
文献类型：
--
作者：
PILCH, PF;CZECH, MP
Rat fat cells or fat cell membranes were briefly subjected to mild proteolysis under conditions where insulin receptors were either free or bound to 125I-labeled insulin. When receptors were then affinity-labeled to visualize the effects of this treatment, receptors that were occupied by ligand during proteolysis exhibited greater rates of degradation than unoccupied receptors. Apparently insulin-receptor interaction induces a change in receptor structure that may be related to signal transmission.
