Effect of solon on gastric mucus viscosity, permeability to hydrogen ion, and susceptibility to pepsin.
Effect of solon on gastric mucus viscosity, permeability to hydrogen ion, and susceptibility to pepsin.
复制标题
solon 对胃粘液粘度、氢离子渗透性和胃蛋白酶敏感性的影响。
作者：
Sarosiek,J;Bilski,J;Tsukada,H;Slomiany,A;Slomiany,BL
采用离体系统研究了新型抗溃疡药索龙（索法酮）对胃粘液粘度、氢离子渗透性和胃蛋白酶降解的影响。分离的胃粘液与solon预孵育产生粘液粘度的显着增强。2.2h × 10 ~（-1）Msolon可使细胞增殖230%。渗透性测定表明，2.2 × 10 ~（-2）Msolon使粘液对氢离子的阻滞能力提高了32%; 2.2 × 10 ~（-1）Msolon使粘液对氢离子的阻滞能力提高了43%。药物对白蛋白的粘度和氢离子阻滞能力无影响。消化活性测定结果表明，梭伦对粘液和白蛋白的蛋白水解速率有抑制作用。在1.0 × 10 ~（-5）M以下，对粘液蛋白水解的抑制率为60%，对白蛋白蛋白水解的抑制率为45%。在体外条件下获得的结果表明，梭伦，通过抑制粘液层的消化性侵蚀，增加其粘度和增强阻止氢离子渗透的能力，加强胃粘膜的完整性，从而可以帮助溃疡愈合。
The effect of a new antiulcer drug, solon (sofalcone), on gastric mucus viscosity, permeability to hydrogen ion and degradation by pepsin was investigated using an in vitro system. Preincubation of the isolated gastric mucus with solon produced a marked enhancement in mucus viscosity. This enhancement was concentration dependent and at 2.2 h× 10-1Msolon reached a value of 230%. Permeability measurements showed that 2.2 × 10-2Msolon increased the retardation ability of mucus to hydrogen ion by 32%, while 43% increase was obtained with 2.2 × 10-1Msolon. The drug had no effect on the viscosity and hydrogen ion retardation capacity of albumin. The results of peptic activity assay indicated that solon had an inhibitory effect on the rate of mucus and albumin proteolysis. The rate of inhibition of peptic activity was proportional to the solon concentration up to 1.0 × 10-5M, at which concentration the proteolysis of mucus was inhibited by 60% and that of albumin by 45%. The results obtained here under in vitro conditions suggest that solon, by inhibiting peptic erosion of the mucus layer, increasing its viscosity and enhancing the ability to impede the hydrogen ion penetration, strengthens the gastric mucosal integrity and thus could aid in ulcer healing.