Oleanolic acid and ursolic acid: Research perspectives
Oleanolic acid and ursolic acid: Research perspectives
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DOI：
10.1016/j.jep.2005.05.024
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发表时间：
2005-08-22
影响因子：
5.4
通讯作者：
Liu, H
中科院分区：
文献类型：
--
作者：
Liu, H
齐墩果酸和熊果酸是植物界普遍存在的三萜类化合物。草药，是人类饮食不可或缺的一部分。在过去的十年里，已经发表了700多篇关于它们的研究文章，反映了我们对这些三萜类化合物的理解的巨大兴趣和进展。这包括从各种植物和草本植物中分离纯化这些三萜类化合物，进行化学修饰以获得更有效的水溶性衍生物，进行其有益作用的药理研究，以及毒性研究。以及这些三萜类化合物在包括抗癌化疗在内的各种疾病中的临床应用，本文对它们的研究前景进行了简要的评论。
Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom. medicinal herbs, and are integral part of the human diet. During the last decade over 700 research articles have been published on their research, reflecting tremendous interest and progress in our understanding of these triterpenoids. This included the isolation and purification of these tritepernoids from various plants and herb,, the chemical modifications to make more effective and water soluble derivatives, the pharmacological research on their beneficial effects, the toxicity studies. and the clinical use of these triterpenoids in various diseases including anticancer chemotherapies, A briefly commentary is attempted here for their research perspectives.