Thyroid Hormones, Oxidative Stress, and Inflammation.
Thyroid Hormones, Oxidative Stress, and Inflammation.
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DOI：
10.1155/2016/6757154
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发表时间：
2016
影响因子：
4.6
通讯作者：
Currò D
中科院分区：
文献类型：
--
作者：
Mancini A;Di Segni C;Raimondo S;Olivieri G;Silvestrini A;Meucci E;Currò D
炎症和氧化应激（OS）是密切相关的过程，在肥胖症和心血管疾病中也有例证。OS也以相互的方式与激素紊乱有关。在影响抗氧化平衡的各种激素中，甲状腺激素起着特别重要的作用，因为甲状腺功能亢进症和甲状腺功能减退症都与动物和人类的OS有关。在这种情况下，非甲状腺疾病综合征（NTIS），通常表现为减少转换甲状腺素（T4）三碘甲状腺原氨酸（T3）在不同的急性和慢性全身性疾病仍然是一个有争议的话题。这种综合征的病理生理机制进行审查，连同脱碘酶的作用，负责T4到T3的转换，在生理和病理情况下的酶。NTIS中OS指数的存在支持了这一假设，即它代表了组织水平的甲状腺功能减退症，而不仅仅是对疾病的适应机制。
Inflammation and oxidative stress (OS) are closely related processes, as well exemplified in obesity and cardiovascular diseases. OS is also related to hormonal derangement in a reciprocal way. Among the various hormonal influences that operate on the antioxidant balance, thyroid hormones play particularly important roles, since both hyperthyroidism and hypothyroidism have been shown to be associated with OS in animals and humans. In this context, the nonthyroidal illness syndrome (NTIS) that typically manifests as reduced conversion of thyroxine (T4) to triiodothyronine (T3) in different acute and chronic systemic conditions is still a debated topic. The pathophysiological mechanisms of this syndrome are reviewed, together with the roles of deiodinases, the enzymes responsible for the conversion of T4 to T3, in both physiological and pathological situations. The presence of OS indexes in NTIS supports the hypothesis that it represents a condition of hypothyroidism at the tissue level and not only an adaptive mechanism to diseases.