Prostate Cancer Detection Using Computed Very High b-value Diffusion-weighted Imaging: How High Should We Go?
Prostate Cancer Detection Using Computed Very High b-value Diffusion-weighted Imaging: How High Should We Go?
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DOI：
10.1016/j.acra.2016.02.003
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发表时间：
2016-06-01
影响因子：
4.8
通讯作者：
Ream, Justin M.
中科院分区：
文献类型：
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作者：
Rosenkrantz, Andrew B.;Parikh, Nainesh;Ream, Justin M.
基本原理和目标：本研究的目的是评估前列腺癌的检测使用广泛的计算b值高达5000 s/mm（2）。材料和方法：这项回顾性的健康保险便携性和责任法案符合研究批准的机构审查委员会同意豁免。49例患者（63 8岁）在前列腺切除术前接受了3 T前列腺磁共振成像。检查包括弥散加权成像（DWI），b值为50和1000 s/mm（2）。通过单指数拟合生成7个计算DWI图像集（b值：1000、1500、2000、2500、3000、4000和5000 s/mm（2））。两名设盲放射科医生（R1 [主治]，R2 [研究员]）独立评价弥散加权图像集的图像质量和主要病变位置。一名单独的非盲放射科医生放置感兴趣区域，以测量肿瘤与外周区（PZ）的对比度。直肠癌切除术的病理结果作为参考标准。采用Jonckheere-Terpstra趋势检验、斯皮尔曼相关系数和基于Logistic回归的广义估计方程对b值之间的测量进行比较。
Rationale and Objectives: The aim of this study was to assess prostate cancer detection using a broad range of computed b-values up to 5000 s/mm(2).Materials and Methods: This retrospective Health Insurance Portability and Accountability Act-compliant study was approved by an institutional review board with consent waiver. Forty-nine patients (63 8 years) underwent 3T prostate magnetic resonance imaging before prostatectomy. Examinations included diffusion-weighted imaging (DWI) with b-values of 50 and 1000 s/mm(2). Seven computed DWI image sets (b-values: 1000, 1500, 2000, 2500, 3000, 4000, and 5000 s/mm(2)) were generated by mono-exponential fit. Two blinded radiologists (R1 [attending], R2 [fellow]) independently evaluated diffusion weighted image sets for image quality and dominant lesion location. A separate unblinded radiologist placed regions of interest to measure tumor-to-peripheral zone (PZ) contrast. Pathologic findings from prostatectomy served as reference standard. Measures were compared between b-values using the Jonckheere-Terpstra trend test, Spearman correlation coefficient, and generalized estimating equations based on logistic regression for correlated data.Results: As b-value increased, tumor-to-PZ contrast and benign prostate suppression for both readers increased (r = +0.65 to +0.71, P