Reference Tables of Two-Locus Haplotype Frequencies for All MHC Marker Loci
Reference Tables of Two-Locus Haplotype Frequencies for All MHC Marker Loci
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所有 MHC 标记基因座的双基因座单倍型频率参考表
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
E. Albert
中科院分区：
文献类型：
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作者：
M. Baur;M. Neugebauer;E. Albert
以下频率表是第九届国际组织相容性研讨会（M。P. Baur等人，基于随机家族的单倍型推断的群体分析，本卷），其中给出了所代表的三个主要种族群体- CAU，ORI，NEG -的定义，计算程序和所得参数估计值的描述）。由于从健康的非选择的黑人家庭中获得的数据很少，我们将来自疾病家庭的无关健康个体的单倍型包括在该人群中。我们意识到，这在HLA与疾病有强关联的情况下引入了偏倚。由于所包括的各种疾病的多样性，这种扭曲将被抵消。另一方面，我们有信心，种族特异性分布的单倍型和不平衡的信息，获得了这个-公认的不寻常的-措施是不受影响，在很大程度上由这种偏见。
The following frequency tables were the basis for the population analysis of the Ninth International Histocompatibility Workshop (M. P. Baur et al., Population Analysis on the Basis of Deduced Haplotypes from Random Families, this volume), where the definition of the represented three major ethnic groups - CAU, ORI, NEG -, the computational procedure, and the description of the resulting parameter estimates are given). Due to the small amount of data available from healthy non-selected Negroid families, we included for this population the haplotypes of unrelated healthy individuals from disease families. We are aware that this introduces a bias in case of strong HLA-disease associations. Some of this distortion will cancel out due to the multiplicity of the various diseases included. On the other hand, we are confident that the information on race-specific distribution of haplotypes and disequilibria gained by this - admittedly unusual - measure is not influenced to a significant degree by this bias.