Iron in skin of mice with three etiologies of systemic iron overload
Iron in skin of mice with three etiologies of systemic iron overload
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DOI：
10.1111/j.0022-202x.2005.23949.x
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发表时间：
2005-12-01
影响因子：
6.5
通讯作者：
Milstone, LM
中科院分区：
文献类型：
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作者：
Adams, BD;Lazova, R;Milstone, LM
在人类血色素沉着症中，组织毒性是组织铁水平的函数。尽管有关于血色素沉着症皮肤毒性的报道，但对全身铁超载个体皮肤中的铁水平知之甚少。我们测量了皮肤铁，并研究了三种全身铁超载小鼠模型的皮肤组织学：血色素沉着症（Hfe）基因缺失的小鼠、高铁饮食的小鼠和注射铁的小鼠。在Hfe（-/-）小鼠中，表皮和真皮中的铁含量出乎意料地与Hfe（+/+）小鼠相同，并且在30周后未检测到组织学异常。高铁饮食使正常动物和Hfe（-/-）动物表皮中的铁含量增加；高铁饮食只增加了Hfe（-/-）小鼠真皮中的铁含量。即使在19周后，皮肤铁的增加也与其他组织学变化无关。注射铁会使表皮和真皮层中的铁含量增加，并使皮肤呈青铜色。这些结果表明，铁在皮肤中的数量和分布取决于铁超载的病因。似乎单独的Hfe缺失和皮肤铁升高都不能解释遗传性血色素沉着症患者的皮肤表现。
In human hemochromatosis, tissue toxicity is a function of tissue iron levels. Despite reports of skin toxicity in hemochromatosis, little is known about iron levels in skin of individuals with systemic iron overload. We measured skin iron and studied skin histology in three mouse models of systemic iron overload: mice with a deletion of the hemochromatosis (Hfe) gene, mice fed a high iron diet, and mice given parenteral injections of iron. In Hfe(-/-) mice, iron content in the epidermis and dermis was unexpectedly the same as in Hfe(+/+) mice, and there were no histological abnormalities detected after 30 wk. A high iron diet produced increased iron in the epidermis of both normal and Hfe(-/-) animals; a high diet increased iron in the dermis only in Hfe(-/-) mice. Increased skin iron was not associated with other histological changes, even after 19 wk. Parenteral administration of iron produced increased iron in the epidermis and dermis, and gave the skin a bronze hue. These results show that the amount and distribution of iron in the skin depends on the etiology of iron overload. It appears that neither Hfe deletion nor elevated skin iron alone can account for cutaneous manifestations reportedly seen in humans with hereditary hemochromatosis.