Renal denervation abolishes hypertension in low-birth-weight offspring from pregnant rats with reduced uterine perfusion
Renal denervation abolishes hypertension in low-birth-weight offspring from pregnant rats with reduced uterine perfusion
复制标题
DOI：
10.1161/01.hyp.0000153319.20340.2a
复制
发表时间：
2005-04-01
期刊：
影响因子：
8.3
通讯作者：
Dwyer, TM
中科院分区：
文献类型：
--
作者：
Alexander, BT;Hendon, AE;Dwyer, TM
低出生体重是人类随后发展为高血压的一个危险因素。我们之前曾报道，怀孕大鼠子宫灌注量减少会导致生长受限的后代更容易患上高血压。这项研究的目的是确定交感神经系统在低出生体重模型中是否在调节高血压中发挥作用。生长受限的雄性后代出生时体重(5.9+/-0.1克)显著低于男性对照后代(6.5+/-0.2克；P<；0.05)。在10周龄时，生长受限的后代和对照的后代被随机分配到一个完整的组(假去神经)或接受双侧肾去神经的组。12周龄时，生长受限组仔鼠平均动脉压(145+/-4 mm Hg；n=7)显著高于对照组仔鼠(134+/-3 mm Hg；P<；0.05；n=9)。双侧肾神经切断导致生长受限子代的动脉压显著降低(125+/-3 mm Hg；P<；0.01；与假生长受限子代相差20 mm Hg；n=8)，而对照组子代的动脉压无显著降低(127+/-3 mm Hg；与假对照组相差7 mm Hg；n=9)。肾去甲肾上腺素含量减少90%证实了肾去神经支配的充分性。因此，这些发现表明肾神经在成年生长受限子代高血压的调节中起重要作用。
Low birth weight is a risk factor for the subsequent development of hypertension in humans. We previously reported that reduced uterine perfusion in the pregnant rat results in growth-restricted offspring predisposed to the development of hypertension. The purpose of this study was to determine whether the sympathetic nervous system plays a role in mediating hypertension in this model of low birth weight. Weight at birth was significantly decreased in male growth-restricted offspring (5.9 +/- 0.1 grams) as compared with male control offspring (6.5 +/- 0.2 grams; P < 0.05). At 10 weeks of age, growth-restricted offspring and control offspring were randomly assigned to either an intact group (sham-denervated) or a group subjected to bilateral renal denervation. For sham-denervated offspring, mean arterial pressure was significantly elevated in growth-restricted offspring (145 +/- 4 mm Hg; n = 7) as compared with control offspring (134 +/- 3 mm Hg; P < 0.05; n = 9) at 12 weeks of age. Bilateral renal denervation resulted in a marked reduction in arterial pressure in growth-restricted offspring (125 +/- 3 mm Hg; P < 0.01; difference of 20 mm Hg versus sham growth-restricted; n = 8) but no significant decrease in control offspring (127 +/- 3 mm Hg; difference of 7 mm Hg versus sham control; n = 9). Adequacy of renal denervation was verified by >90% reduction in renal norepinephrine content. Therefore, these findings indicate the renal nerves play an important role in mediating hypertension in adult growth-restricted offspring.