Histological and microradiographic evaluation of hydrated and hardened alpha-tricalcium phosphate/calcium phosphate dibasic mixtures.
Histological and microradiographic evaluation of hydrated and hardened alpha-tricalcium phosphate/calcium phosphate dibasic mixtures.
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水合和硬化α-磷酸三钙/磷酸二氢钙混合物的组织学和显微放射学评估。
DOI：
10.1016/0142-9612(94)90221-6
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发表时间：
1994
期刊：
影响因子：
14
通讯作者：
M. Hirano
中科院分区：
文献类型：
--
作者：
K. Kurashina;A. Ogiso;A. Kotani;H. Takeuchi;M. Hirano
本文报道了水化预硬化α-磷酸三钙（α-TCP）和磷酸氢钙（DCPD）混合物植入兔下颌骨后的骨组织反应。在1个月的种植体中，观察到新骨形成沿着材料表面靠近宿主骨，并且在一些地方观察到新骨和宿主骨通过薄骨桥连接。在3个月的种植体中，新形成的骨填充了材料和宿主骨之间的大部分差距，在6个月的种植体中，它几乎包围了材料的整个表面。在所有植入期间，新骨与材料直接接触。骨反应与羟基磷灰石（HA）基本一致。在3个月和6个月的植入物中观察到材料吸收。结论：预硬化α-TCP/DCPD混合物与骨组织具有良好的生物相容性，与HA相当，植入兔体内后可吸收。应进行进一步的研究，以评估吸收和白色带形成的材料变化。
Bone tissue responseto pre-hardened α-tricalcium phosphate (α-TCP) and calcium phosphate dibasic (DCPD) mixture by hydration was studied histologically and microradiographically after implanting on the inferior aspect of the mandible in rabbits. In 1-month implants, new bone formation was observed along the surface of the material near the host bone, and connection of new and host bone through thin bone bridges was seen in some places. In 3-month implants, newly formed bone filled the greater part of the gap between material and host bone, and in 6-month implants, it surrounded almost all the surface of the material. New bone was in direct contact with the material in all implant periods. The bone response was essentially consistent with that to hydroxyapatite (HA). Resorption of the material was noticed in 3- and 6-month implants. It was concluded that pre-hardened α-TCP/DCPD mixture has good biocompatibility with bone tissue equal to HA and that it resorbs when implanted in rabbit. Further research should be performed to evaluate the material changes of resorption and formation of the white zone.