Rat sex and strain differences in responses to stress
Rat sex and strain differences in responses to stress
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DOI：
10.1016/s0031-9384(02)00645-5
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发表时间：
2002-04-01
影响因子：
2.9
通讯作者：
Faraday, MM
中科院分区：
文献类型：
--
作者：
Faraday, MM
对压力的敏感性与各种生理和心理障碍的发展有关。迄今为止的研究主要集中在极端压力表型，主要研究男性的反应，使用有限的因变量，并包括有限数量的测量时间点。本实验旨在解决这些局限性。评价了成年雄性和雌性Sprague-Dawley和Long-Evans大鼠对每日免疫应激（20 min/天）的喂养、体重、旷场活动、声惊吓反射（ASR）和前脉冲抑制（PPI）反应，持续3周。压力显着降低喂养和体重的男性，但一般不女性。在Long-Evans男性中效果最大。压力降低15分钟的活动水平，男性在压力第1天，但不是在其他日子。应激不影响15分钟的活动水平的长埃文斯女性，但减少15分钟的活动水平的Sprague道利女性在每个测量日。ASR对应激的反应因大鼠品系而异; PPI反应百分比因大鼠品系和性别而异。压力增加惊吓反应的Sprague-Dawley男性和女性，但不长埃文斯男性和女性。压力降低PPI的Long-Evans女性在每个测量日，但没有其他组。这些结果表明，品系和性别的大鼠是重要的考虑在评估行为和生理反应的压力。(C)2002年爱思唯尔科学公司All rights reserved.
Sensitivity to stress has been linked to the development of a variety of physical and psychological disorders. Studies to-date have focused on extreme stress phenotypes, have studied mostly male responses, have used limited dependent variables, and have included a limited number of measurement time points. The present experiment was designed to address these limitations. Feeding, body weight, open-field activity, acoustic startle reflex (ASR), and prepulse inhibition (PPI) responses of adult male and female Sprague-Dawley and Long-Evans rats to daily immunobilization stress (20 min/day) were evaluated for 3 weeks. Stress significantly decreased feeding and body weight of males but generally not of females. Effects were greatest in Long-Evans males. Stress decreased 15-min activity levels for males on Stress Day 1, but not on other days. Stress did not affect 15-min activity levels of Long-Evans females but decreased 15-min activity levels of Sprague Dawley females on every measurement day. ASR responses to stress differed based on rat strain; percent PPI responses differed based on rat strain and sex. Stress increased startle responses of Sprague-Dawley males and females but not of Long-Evans males and females. Stress reduced PPI of Long-Evans females on every measurement day but not of other groups. These findings indicate that strain and sex of rat is important to consider in evaluating behavioral and physiological responses to stress. (C) 2002 Elsevier Science Inc. All rights reserved.