Mycoplasmas in the etiology of multifactorial respiratory disease
Mycoplasmas in the etiology of multifactorial respiratory disease
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DOI：
10.1093/ps/77.8.1146
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发表时间：
1998-08-01
期刊：
影响因子：
4.4
通讯作者：
Kleven, SH
中科院分区：
文献类型：
--
作者：
Kleven, SH
对商业家禽具有致病性的禽支原体、鸡和火鸡中的鸡毒支原体和滑膜支原体以及火鸡中的火鸡支原体和衣阿华支原体是蛋传播的感染，并且在临床表现上表现出广泛的变化。鸡毒支原体菌株在毒力、组织嗜性和抗原组成方面差异很大，并且能够改变主要表面抗原蛋白的表达。虽然研究较少，但M. Synoptera，M.和M.爱荷华州似乎表现出类似的可变性。支原体菌株之间的种内变异性及其与其他致病因素相互作用的能力解释了临床表现的广泛变异性、诊断困难、其在宿主体内长时间持续存在的能力以及控制和根除方案中涉及的许多困难。众所周知，支原体与其他感染因子和环境因素相互作用，导致临床疾病。当并发感染最小化并提供最佳环境条件时，支原体感染临床表现的控制得到简化。
The avian mycoplasmas pathogenic for commercial poultry, Mycoplasma gallisepticum and Mycoplasma synoviae in chickens and turkeys, and Mycoplasma meleagridis and Mycoplasma iowae in turkeys are egg-transmitted infections and exhibit wide variations in clinical manifestations. Mycoplasma gallisepticum strains vary widely in virulence, tissue tropism, and antigenic makeup and have the ability to alter the expression of major surface antigenic proteins. Although less well studied, strains of M. synoviae, M. meleagridis, and M. iowae appear to exhibit similar variability. Intraspecies variability among mycoplasma strains and their ability to interact with other disease-producing factors explain the wide variability of clinical manifestations, difficulties in diagnosis,their ability to persist within the host for long periods of time, and many of the difficulties involved in control and eradication programs. Mycoplasmas are also well known for their interactions with other infectious agents and environmental factors in producing clinical disease. Control of the clinical manifestations of Mycoplasma infections is simplified when concurrent infections are minimized and optimum environmental conditions are provided.