Nucleosides & nucleotides. 118. Synthesis of oligonucleotides containing a novel 2′-deoxyuridine analogue that carries an aminoalkyl tether at 1′-position; stabilization of duplex formation by an intercalatin group accommodated in the minor groove
Nucleosides & nucleotides. 118. Synthesis of oligonucleotides containing a novel 2′-deoxyuridine analogue that carries an aminoalkyl tether at 1′-position; stabilization of duplex formation by an intercalatin group accommodated in the minor groove
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核苷和核苷酸 118. 含有新型 2-脱氧尿苷类似物的寡核苷酸的合成，该类似物在 1 位带有氨烷基系链，通过小沟中的插入基团稳定双链体的形成。
DOI：
10.1016/s0960-894x(01)81240-3
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发表时间：
1993
影响因子：
2.7
通讯作者：
A. Matsuda
中科院分区：
文献类型：
--
作者：
A. Dan;Y. Yoshimura;A. Ono;A. Matsuda
合成了一种在糖部分的 1' 位带有氨基烷基链的新型 2'-脱氧尿苷类似物，并将其掺入寡核苷酸中，然后将嵌入基团连接到氨基上。由寡核苷酸和互补链组成的双链体比未修饰的亲本双链体更稳定。
A novel 2′-deoxyuridine analogue carrying an aminoalkyl tether at 1′-position of the sugar moeity was synthesized and incorporated into oligonucleotides, then an intercalating group was attached to the amino group. Duplexes, consisting of the oligonucleotides and a complementary strand, were more stable than a unmodiifed parent duplex.