BACTERIAL INTERFERENCE IN THERAPY OF RECURRENT STAPHYLOCOCCAL INFECTIONS - MULTIPLE ABSCESSES DUE TO IMPLANTATION OF 502A STRAIN OF STAPHYLOCOCCUS
BACTERIAL INTERFERENCE IN THERAPY OF RECURRENT STAPHYLOCOCCAL INFECTIONS - MULTIPLE ABSCESSES DUE TO IMPLANTATION OF 502A STRAIN OF STAPHYLOCOCCUS
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DOI：
10.1056/nejm196611242752104
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发表时间：
1966-01-01
影响因子：
158.5
通讯作者：
KOENIG, MG
中科院分区：
文献类型：
--
作者：
DRUTZ, DJ;VANWAY, MH;KOENIG, MG
1例复发性疖和潜在未诊断皮肤病患者通过使用502A金黄色葡萄球菌菌株进行细菌干扰治疗。鼻粘膜成功地用502 A定殖，尽管未实现原始葡萄球菌植物群的消除。葡萄球菌病变的发生率在该计划中降低。然而，502A是从所有的，但随后发生的两次在纯培养物中，除了1。这是第1例报告的502A植入后葡萄球菌疾病病例。当502A菌株可能有益时，这一经验并不构成使用502A菌株的禁忌症，但很明显，当存在适当的宿主因素时，这种“相对非致病性微生物”可产生葡萄球菌疾病。
A patient with recurrent furunculosis and an underlying undiagnosed skin disease was treated by means of bacterial interference utilizing the 502A strain of Staphylococcus aureus. The nasal mucosa was successfully colonized with 502A although elimination of the original staphylococcal flora was not achieved. The incidence of staphylococcal lesions was reduced on this program. However, 502A was isolated from all but 1 of the abscesses that did occur subsequently, twice in pure culture. This is the 1st reported case of staphylococcal disease that followed the implantation of the 502A staphylococcus. This experience does not constitute a contraindication to the use of the 502A strain when it may be of benefit, but it is apparent that this "relatively nonpathogenic micro-organism" can produce staphylococcal disease when appropriate host factors exist.