Reduction of noise due to systematic uncertainties in 113mIn SPECT imaging using information theory
Reduction of noise due to systematic uncertainties in 113mIn SPECT imaging using information theory
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DOI：
10.1016/j.compbiomed.2009.03.001
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发表时间：
2009-05-01
影响因子：
7.7
通讯作者：
Iyengar, Puneeth
中科院分区：
文献类型：
--
作者：
Kumar, P. T. Krishna;Phoha, Vir V.;Iyengar, Puneeth
使用放射性药物的SPECT图像受到随机和系统不确定性引起的噪声的限制。到目前为止，所有的努力都只针对最小化随机不确定性，而没有尝试过最小化由于系统不确定性引起的噪声。由于这些放射性药物在其形成过程中遇到许多系统的不确定性，我们构建了协方差矩阵与这些系统的不确定性的γ计数率的In-113 m。我们描述了基于行列式不等式技术和互信息最小化概念的算法，该算法逐个元素地处理协方差矩阵，以最小化由In-113 m SPECT成像中的系统不确定性引起的噪声，并描述了该算法对实验人员设计和改进其测量和仪器过程的实用性。(C)2009爱思唯尔有限公司版权所有。
SPECT images using radiopharmaceuticals are limited by noise caused by both random and systematic uncertainties. All the efforts so far have been directed only to minimize the random uncertainty and no attempt has ever been made to minimize the noise due to systematic uncertainty. As these radiopharmaceuticals encounter many systematic uncertainties during their formation, we constructed the covariance matrix with some of these systematic uncertainties for the gamma count rate of In-113m. we describe the algorithm we have developed based on the technique of determinant inequalities and the concept of minimization of mutual information to process the covariance matrix element by element to minimize the noise caused by systematic uncertainty in the SPECT imaging of In-113m and its utility to experimentalists to design and improve their process of measurement and instrumentation. (C) 2009 Elsevier Ltd. All rights reserved.