Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria
Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria
复制标题
DOI：
10.3324/haematol.2012.065854
复制
发表时间：
2012-11-01
期刊：
影响因子：
--
通讯作者：
Roberts, David J.
中科院分区：
文献类型：
--
作者：
Casals-Pascual, Climent;Huang, Honglei;Roberts, David J.
在急性疟疾中，铁调素水平很高，铁吸收有限。调节铁调素分泌的机制仍不明确。我们测量了100名肯尼亚急性恶性疟疾和不同程度贫血儿童的铁调素浓度和细胞因子。Hepcidin在入院时升高，在治疗后1周和1个月显著下降。铁调素与血红蛋白的相关性不是线性的，并且在严重的疟疾性贫血中铁调素非常低。寄生虫密度、IL-10和IL-6与hepcidin浓度显著相关。铁调素对急性疟疾的反应支持急性疟疾感染期间铁螯合的概念，并表明急性疟疾期间铁的施用是徒劳的。这些数据表明，补铁政策应考虑到大多数急性疟疾患者治疗后一周内铁调素水平较高和铁利用率可能较差。
Hepcidin levels are high and iron absorption is limited in acute malaria. The mechanism(s) that regulate hepcidin secretion remain undefined. We have measured hepcidin concentration and cytokines in 100 Kenyan children with acute falciparum malaria and different degrees of anemia. Hepcidin was increased on admission and fell significantly one week and one month after treatment. The association of hepcidin with hemoglobin was not linear and hepcidin was very low in severe malarial anemia. Parasite density, IL-10 and IL-6 were significantly associated with hepcidin concentration. Hepcidin response to acute malaria supports the notion of iron sequestration during acute malaria infection and suggests that iron administration during acute malaria is futile. These data suggest iron supplementation policies should take into account the high hepcidin levels and probable poor utilization of iron for up to one week after treatment for the majority of patients with acute malaria.