Immunomodulatory effects of (n-3) fatty acids: Putative link to inflammation and colon cancer
Immunomodulatory effects of (n-3) fatty acids: Putative link to inflammation and colon cancer
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DOI：
10.1093/jn/137.1.200s
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发表时间：
2007-01-01
影响因子：
4.2
通讯作者：
McMurray, David N.
中科院分区：
文献类型：
--
作者：
Chapkin, Robert S.;Davidson, Laurie A.;McMurray, David N.
慢性炎症和结直肠癌密切相关。尽管炎症相关胃肠道癌发生的总体机制是复杂的，但很明显，顺铂治疗对肿瘤进展和恶性转化是有效的。从饮食的角度来看，含有（n-3）多不饱和脂肪酸（PUFA）的鱼油具有抗氧化特性，但多年来其机制仍然不清楚。的相关性;肠内免疫系统，我们表明（n-3）PUFA喂养通过直接抑制Th 1细胞发育（即，克隆扩增）。这是值得注意的，因为Th 1细胞介导炎性疾病和对细胞内病原体或过敏性超敏反应的抗性，而Th 2细胞介导对细胞外病原体的抗性。因此，由（n-3）PUFA诱导的T细胞亚群平衡和功能的任何变化都是重要的，因为预期结果将抑制自身免疫性疾病的发展，并可能抑制结肠癌的发生。（n-3）PUFA的免疫调节作用如何精确地影响炎症相关的结肠肿瘤发展是正在进行的研究的主题。
Chronic inflammation and colorectal cancer are closely linked. Although the overall mechanisms of inflammation-associated gastrointestinal carcinogenesis are complex, it is clear that antiinflammatory therapy is efficacious against neoplastic progression and malignant conversion. From a dietary perspective, fish oil containing (n-3) polyunsaturated fatty acids (PUFAs) has antiinflammatory properties, but for years the mechanism has remained obscure. Of relevance to the ;immune system in the intestine, we showed that (n-3) PUFA feeding alters the balance between CD4(+) T-helper (Th1 and Th2) subsets by directly suppressing Th1 cell development (i.e., clonal expansion). This is noteworthy because Th1 cells mediate inflammatory diseases and resistance to intracellular pathogens or allergic hypersensitivity, and Th2 cells mediate resistance to extracellular pathogens. Therefore, any changes induced by (n-3) PUFAs in T-cell subset balance and function are important because the outcome is expected to suppress the development of autoimmune diseases and possibly the occurrence of colon cancer. Precisely how the immunomodulatory effects of (n-3) PUFAs influence inflammation-associated colonic tumor development is the subject of an ongoing investigation.