COGNITION IS RELATED TO RESTING-STATE SMALL-WORLD NETWORK TOPOLOGY: AN MAGNETOENCEPHALOGRAPHIC STUDY
COGNITION IS RELATED TO RESTING-STATE SMALL-WORLD NETWORK TOPOLOGY: AN MAGNETOENCEPHALOGRAPHIC STUDY
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DOI：
10.1016/j.neuroscience.2010.11.039
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发表时间：
2011-02-17
期刊：
影响因子：
3.3
通讯作者：
Stam, C. J.
中科院分区：
文献类型：
--
作者：
Douw, L.;Schoonheim, M. M.;Stam, C. J.
大脑网络和认知最近开始引起人们的注意：研究表明，更有效地连接休息状态的大脑网络确实与更好的认知表现相关。“小世界”大脑网络将局部隔离与全局整合联合收割机结合起来，从而有助于信息处理。此外，最近的研究表明，性别效应可能存在于网络动态及其与认知的相关性。本研究报告了健康受试者的静息态脑功能拓扑与整体和特定领域认知表现之间的关系以及可能的性别差异。健康参与者接受神经心理学测试，其中个人得分被转换为z分数。在确定每对传感器之间的功能连接性后，对静息状态、闭眼脑磁图（MEG）数据进行网络分析。计算了6个频段的聚类系数（局部专业化）、平均路径长度（整体整合和效率）和“小世界指数”（即聚类与路径长度之比）。14名男性和14名女性参与者。更好的总体认知表现与θ波段的局部连通性增加、较高的聚类系数（δ和θ波段）和较高的小世界性（θ和较低的γ波段）有关。女性在δ带中表现出较少的聚集和较短的路径长度。女性的网络拓扑结构与认知功能无显著相关。相比之下，男性的认知得分更高，与θ波段聚类和小世界性增加有关。这些结果为功能性脑网络拓扑结构对认知功能的价值提供了进一步的证据，并表明性别在这方面是一个重要因素。(C)2011年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Brain networks and cognition have recently begun to attract attention: studies suggest that more efficiently wired resting-state brain networks are indeed correlated with better cognitive performance. "Small-world" brain networks combine local segregation with global integration, hereby subserving information processing. Furthermore, recent studies implicate that gender effects may be present in both network dynamics and its correlations with cognition. This study reports on the relation between resting-state functional brain topology with overall and domain-specific cognitive performance in healthy participants and possible gender differences herein. Healthy participants underwent neuropsychological tests, of which individual scores were converted to z-scores. Network analysis was performed on resting-state, eyes-closed magnetoencephalography (MEG) data, after determining functional connectivity between each pair of sensors. The clustering coefficient (local specialization), average path length (overall integration and efficiency) and "small-world index" (i.e. ratio between clustering and path length) were calculated in six frequency bands. 14 male and 14 female participants were included. Better total cognitive performance was related to increased local connectivity in the theta band, higher clustering coefficient (in delta and theta bands) and higher small-worldness (in theta and lower gamma bands). Women showed less clustering and shorter path length in the delta band. There were no significant correlations between network topology and cognitive functioning in females. In contrast, higher cognitive scores in men were associated with increased theta band clustering and small-worldness. These results provide further evidence for the value of functional brain network topology for cognitive functioning and suggest that gender is an important factor in this respect. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.