Necrotizing enterocolitis comes in different forms: Historical perspectives and defining the disease
Necrotizing enterocolitis comes in different forms: Historical perspectives and defining the disease
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DOI：
10.1016/j.siny.2018.07.004
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发表时间：
2018-12-01
影响因子：
3
通讯作者：
Caplan, M.
中科院分区：
文献类型：
--
作者：
Neu, J.;Modi, N.;Caplan, M.
通常被称为坏死性小肠结肠炎(NEC)的疾病的具体原因一直难以确定，主要是因为越来越明显的是，这种疾病代表了不止一种具有多因素致病机制的疾病。此外，在更好地描述我们所称的这种疾病的不同子集之前，找到明确和一致的诊断生物标志物将是困难的。在本介绍性章节中，我们讨论新生儿中经常被称为“NEC”的不同疾病实体。我们希望这将为更有重点地研究和开发至少针对这种疾病最常见形式的预防措施奠定基础。
The specific cause of what is commonly referred to as necrotizing enterocolitis (NEC) disease has been elusive largely because it is becoming clear that this entity represents more than one disease with multifactorial pathogenic mechanisms. Furthermore, finding clear and consistent diagnostic biomarkers will be difficult until the different subsets of what we are calling this disease are better delineated. In this introductory chapter, we discuss different disease entities that are frequently termed "NEC" in the newborn infant. We hope this will set the stage for more focused research and development of preventative measures for at least the most common forms of this disease.