From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Indocyanine Green Loaded Gold Nanorod@liposome Core-Shell Nanoparticles in Liver Cancer
From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Indocyanine Green Loaded Gold Nanorod@liposome Core-Shell Nanoparticles in Liver Cancer
复制标题
从检测到切除：吲哚菁绿金纳米棒@脂质体核壳纳米颗粒在肝癌中的光声断层扫描和手术指导
DOI：
10.1021/acs.bioconjchem.7b00065
复制
发表时间：
2017-04-01
影响因子：
4.7
通讯作者：
Wang, Kun
中科院分区：
文献类型：
--
作者：
Guan, Tianpei;Shang, Wenting;Wang, Kun
传统的影像学方法在诊断小于10mm或没有典型的高血管特征的肝癌时遇到了挑战。新兴的光声层析成像技术具有深穿透性和高空间分辨率的成像能力，可能为无创肝癌的诊断提供更好的诊断效果。此外，近红外荧光成像引导下的肝切除术被证明能够识别毫米级别的结节。因此，合适的光声和荧光双模成像探头有利于患者早期诊断和完全切除。在这项研究中，我们制造了吲哚菁绿负载金nanorod@liposome核壳纳米颗粒（Au@liposome ICG）来整合这两种成像策略。这些纳米颗粒具有优异的生物相容性，高稳定性和增强的双模型成像信号。接下来，我们探讨了它们在原位肝癌小鼠模型中的肿瘤检测和手术指导的有效性。组织学分析证实了探针在肝癌检测和切除中的准确性。这种新型的双模纳米探针有望为肝癌的早期诊断和更好的手术效果带来希望，并具有巨大的临床转化潜力。
Conventional imaging methods encounter challenges in diagnosing liver cancer that is less than 10 mm or without typical hypervascular features. With deep penetration and high spatial resolution imaging capability, the emerging photoacoustic tomography may offer better diagnostic efficacy for noninvasive liver cancer detection. Moreover, near infrared fluorescence imaging-guided hepatectomy was proven to be able to identify nodules at the millimeter level. Thus, suitable photoacoustic and fluorescence dual-modality imaging probe may benefit patients in early diagnosis and complete resection. In this study, we fabricated indocyanine green loaded gold nanorod@liposome core shell nanoparticles (Au@liposome ICG) to integrate both imaging strategies. These nanoparticles exhibit superior biocompatibility, high stability, and enhanced dual-model imaging signals. Next, we explored their effectiveness of tumor detection and surgery guidance in orthotopic liver cancer mouse models. Histological analysis confirmed the accuracy of the probe in liver cancer detection and resection. This novel dual modality nanoprobe holds promise for early diagnosis and better surgical outcome of liver cancer and has great potential for clinical translation.