Relation of Biventricular Strain and Dyssynchrony in Repaired Tetralogy of Fallot Measured by Cardiac Magnetic Resonance to Death and Sustained Ventricular Tachycardia
Relation of Biventricular Strain and Dyssynchrony in Repaired Tetralogy of Fallot Measured by Cardiac Magnetic Resonance to Death and Sustained Ventricular Tachycardia
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DOI：
10.1016/j.amjcard.2014.12.024
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发表时间：
2015-03-01
影响因子：
2.8
通讯作者：
Harrild, David M.
中科院分区：
文献类型：
--
作者：
Moon, Thomas J.;Choueiter, Nadine;Harrild, David M.
修复型法洛四联症(TOF)患者可以测量到心室张力和不同步性，但其对临床预后的影响尚不清楚。这项研究的目的是调查心脏磁共振特征跟踪测量的心室张力和不同步是否与死亡和持续性室性心动过速有关。将死亡或伴发室性心动过速的TOF患者(TOF例，n=16)与年龄匹配的无不良结局的TOF患者(TOF对照组，n=32)进行比较。使用心脏磁共振特征跟踪软件分析每个患者的脑室中段短轴和四腔电影稳态自由进动图像。比较两组间左、右室最大周向和纵向应变及不同步指标。与TOF对照组相比，TOF病例组两个左心室的中位应变值均显著降低(周向：17%对23%，p=0.003；纵向：13%对18%，p=0.05)。
Ventricular strain and dyssynchrony can be measured in patients with repaired tetralogy of Fallot (TOF), but their effect on clinical outcomes is poorly understood. The purpose of this study was to investigate if ventricular strain and dyssynchrony measured by cardiac magnetic resonance feature tracking are associated with death and sustained ventricular tachycardia. Patients with TOF who died or had ventricular tachycardia (TOF case, n = 16) were compared with age-matched patients with TOF with no adverse outcome (TOF control, n = 32). For each patient, midventricular short-axis and 4-chamber cine steady-state free precession images were analyzed using cardiac magnetic resonance feature-tracking software. Peak left ventricular (LV) and right ventricular (RV) global circumferential and longitudinal strain and indexes of dyssynchrony were compared between groups. Compared with the TOF control group, median strain values were significantly lower for the TOF case group for both the LV (circumferential: 17% vs 23%, p = 0.003; longitudinal: 13% vs 18%, p