Incidence of cardiovascular diseases and associated risk factors among subjects with type 2 diabetes - an 11-year follow up study.
Incidence of cardiovascular diseases and associated risk factors among subjects with type 2 diabetes - an 11-year follow up study.
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DOI：
10.1016/j.ihj.2013.12.009
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发表时间：
2014-01
影响因子：
1.5
通讯作者：
Viswanathan V
中科院分区：
文献类型：
--
作者：
Umamahesh K;Vigneswari A;Surya Thejaswi G;Satyavani K;Viswanathan V
本研究计划评估11年期间心血管疾病（CVD）事件的发展，并确定可预测2型糖尿病受试者CVD发作的相关风险因素。本研究检索并分析了2000年1月至2011年12月期间在三级糖尿病护理中心就诊的7800例患者队列中249例2型糖尿病患者（男性：女性149：100）的回顾性数据。从病例记录中收集社会人口学和习惯性危险因素、基线糖尿病病程、HbA 1c和CVD发作时间及其危险因素。采用人年法计算CVD发病率。进行二元逻辑回归分析，以确定与CVD及其危险因素相关的预测因子。糖尿病受试者中CVD的发生率为5.6例/1000人-年。近60%的人在11年期间患上了高血压和血脂异常或两者兼而有之。最常见的并发症是神经病变（14.4%）。吸烟[OR（95%CI）] [9.26（1.6-54.9）]（p = 0.014）和大量饮酒[8.7（1.1-69.8）]（p = 0.04）与CVD显著相关。较高的BMI与高血压和血脂异常显著相关[2.4（1.3-4.3）]（p = 0.003）。在本研究人群中，吸烟和大量饮酒与CVD显著相关，BMI增加与2型糖尿病受试者的高血压和血脂异常显著相关。这些发现强调了早期识别和修改糖尿病患者CVD事件相关危险因素的必要性。
This study was planned to assess the development of cardiovascular disease (CVD) events over an 11-year period and to identify the associated risk factors that could predict the onset of CVD among subjects with type 2 diabetes. Retrospective data of 249 patients (M:F 149:100) with type 2 diabetes, from a cohort of 7800 patients, attending a tertiary care center for diabetes from January 2000 to December 2011 were retrieved and analyzed for this study. Sociodemographic and habitual risk factors, baseline diabetes duration, HbA1c and time of onset of CVD and its risk factors were collected from case records. Person-years method was used to calculate incident rate of CVD. Binary logistic regression analyses were done to identify predictors associated with CVD and its risk factors. Incidence of CVD among subjects with diabetes was 5.6 cases/1000 person-years. Nearly 60% developed hypertension and dyslipidemia or both during the 11-year period. The most common complication was neuropathy (14.4%). Smoking [OR (95%CI)] [9.26 (1.6–54.9)] (p = 0.014) and heavy alcohol consumption [8.7 (1.1–69.8)] (p = 0.04) were significantly associated with CVD. Higher BMI was significantly associated with hypertension and dyslipidemia [2.4 (1.3–4.3)] (p = 0.003). Smoking and heavy alcohol consumption were significantly associated with CVD, and increased BMI was significantly associated with hypertension and dyslipidemia among subjects with type 2 diabetes in this study population. These findings emphasize the need for early identification and modification of risk factors associated with CVD events in patients with diabetes.