Perinatal profile of very low birthweight infants under a universal newborn hearing screening programme in a developing country: A case-control study
Perinatal profile of very low birthweight infants under a universal newborn hearing screening programme in a developing country: A case-control study
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DOI：
10.3109/17518420903468472
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发表时间：
2010-01-01
影响因子：
1.3
通讯作者：
Olusanya, Bolajoko O.
中科院分区：
文献类型：
--
作者：
Olusanya, Bolajoko O.
目的：确定在尼日利亚拉各斯市中心妇产医院分娩的极低出生体重（VLBW）婴儿（≥ 2500 g）的围产期特征和发育风险。听力状态通过两阶段筛选确定与瞬态诱发耳声发射（TEOAE），然后自动听觉脑干反应（AABR）。母亲和婴儿的因素与VLBW确定使用无条件和有条件的多变量logistic回归analysis.Results：所有45 VLBW单胎（平均体重1.3 +/- 0.1公斤）在研究期间与225对照组（平均体重3.4 +/- 0.5公斤）相匹配。基于非匹配和匹配分析，VLBW与母亲职业、缺乏产前保健、低5分钟Apgar评分和高胆红素血症相关。此外，极低出生体重婴儿与听力筛查失败或不完整的结果显著相关。四（10.5%）的38名婴儿测试AABR失败，但没有返回的诊断评估和一个孩子以前通过TEOAE.Conclusions：VLBW婴儿在资源匮乏的设置与感音神经性听力损失和其他围产期结局的风险，可能会损害他们的最佳发展在幼儿期。
Objective: To determine the perinatal profile and developmental risks of very low birth weight (VLBW) infants (= 2500 g) infants delivered in an inner-city maternity hospital in Lagos, Nigeria. Hearing status was determined by two-stage screening with transient evoked otoacoustic emissions (TEOAE) followed by automated auditory brainstem response (AABR). Maternal and infant factors associated with VLBW were determined using unconditional and conditional multivariable logistic regression analyses.Results: All 45 VLBW singletons (mean weight 1.3 +/- 0.1 kg) during the study period were matched with 225 controls (mean weight 3.4 +/- 0.5 kg). VLBW was associated with maternal occupation, lack of antenatal care, low 5-minute Apgar score and hyperbilirubinemia based on unmatched and matched analyses. Additionally, VLBW infants were significantly associated with failed or incomplete hearing screening outcomes. Four (10.5%) of the 38 infants tested with AABR failed, but none returned for diagnostic evaluation and one child had previously passed TEOAE.Conclusions: VLBW infants in resource-poor settings are associated with the risk of sensorineural hearing loss and other perinatal outcomes that may potentially compromise their optimal development in early childhood.