Oocyte donation: clinical and practical aspects
Oocyte donation: clinical and practical aspects
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DOI：
10.1016/s0303-7207(99)00229-4
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发表时间：
2000-03-30
影响因子：
4.1
通讯作者：
Pados, G
中科院分区：
文献类型：
--
作者：
Tarlatzis, BC;Pados, G
捐献卵子对于缺乏卵巢功能的妇女是一种有效的治疗方式，但对于重复体外受精(IVF)周期不能产生足够数量的卵母细胞的妇女以及那些有传播遗传病风险的妇女也是如此。卵巢功能衰竭的女性需要人工月经周期，以产生与卵巢功能正常的女性相似的子宫内膜生长和分化。供者和受者的周期同步是强制性的，因为植入的窗口相当有限。捐献卵子治疗的良好结果证实了这种辅助生殖技术可以为治疗这类患者的不孕症提供一种新的方法。然而，高龄育龄妇女的怀孕与明显更多的产科并发症和更高的围产期发病率和死亡率有关。此外，年迈的父母患严重或危及生命的疾病的几率要高得多。因此，必须进行仔细的体检和广泛的咨询，同时考虑到这一程序的心理社会影响，特别是准儿童的最佳利益。(C)2000爱思唯尔爱尔兰科学有限公司。保留所有权利。
Oocyte donation is an effective treatment modality for women lacking functioning ovaries, but also for women in whom repetitive in-vitro fertilization (IVF) cycles did not result in the development of adequate number of oocytes as well as for those at risk of transmitting genetic diseases. In women with ovarian failure, artificial menstrual cycles are required in order to produce endometrial growth and differentiation similar to that in women with normal ovarian function. Synchronization of donor's and recipient's cycles is mandatory, since the window of implantation is rather limited. The excellent results of oocyte donation treatment confirm that this assisted reproduction technique can provide a novel approach for the treatment of infertility in these groups of patients. Nevertheless, pregnancies in women of advanced reproductive age are associated with significantly more obstetrical complications and higher perinatal morbidity and mortality rates. Furthermore, aging parents have considerably higher chances to develop serious or life-threatening diseases. Thus, careful medical screening and extensive counselling is mandatory, taking into account the psychosocial ramifications of the procedure and, especially, the best interest of the child-to-be. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.